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Mitochondrial DNA damage triggers mitochondrial dysfunction and apoptosis in oxidant-challenged lung endothelial cells.
Ruchko M, Gorodnya O, LeDoux SP, Alexeyev MF, Al-Mehdi AB, Gillespie MN. Ruchko M, et al. Among authors: gillespie mn. Am J Physiol Lung Cell Mol Physiol. 2005 Mar;288(3):L530-5. doi: 10.1152/ajplung.00255.2004. Epub 2004 Nov 24. Am J Physiol Lung Cell Mol Physiol. 2005. PMID: 15563690 Free article.
In pulmonary artery endothelial cells (PAECs), oxidant-mediated damage to mitochondrial DNA (mtDNA) seems to be critical in initiating cytotoxicity inasmuch as overexpression of the mitochondrially targeted human DNA repair enzyme, human Ogg1 (hOgg1), prevents both mtDNA damage a …
In pulmonary artery endothelial cells (PAECs), oxidant-mediated damage to mitochondrial DNA (mtDNA) seems to be critical in initiating cytot …
Controlled DNA "damage" and repair in hypoxic signaling.
Gillespie MN, Pastukh VM, Ruchko MV. Gillespie MN, et al. Respir Physiol Neurobiol. 2010 Dec 31;174(3):244-51. doi: 10.1016/j.resp.2010.08.025. Epub 2010 Sep 8. Respir Physiol Neurobiol. 2010. PMID: 20831905 Free PMC article. Review.
Mitochondrial-targeted DNA repair enzyme 8-oxoguanine DNA glycosylase 1 protects against ventilator-induced lung injury in intact mice.
Hashizume M, Mouner M, Chouteau JM, Gorodnya OM, Ruchko MV, Potter BJ, Wilson GL, Gillespie MN, Parker JC. Hashizume M, et al. Among authors: gillespie mn. Am J Physiol Lung Cell Mol Physiol. 2013 Feb 15;304(4):L287-97. doi: 10.1152/ajplung.00071.2012. Epub 2012 Dec 14. Am J Physiol Lung Cell Mol Physiol. 2013. PMID: 23241530 Free PMC article.
Mitochondrial DNA damage-associated molecular patterns mediate a feed-forward cycle of bacteria-induced vascular injury in perfused rat lungs.
Kuck JL, Obiako BO, Gorodnya OM, Pastukh VM, Kua J, Simmons JD, Gillespie MN. Kuck JL, et al. Among authors: gillespie mn. Am J Physiol Lung Cell Mol Physiol. 2015 May 15;308(10):L1078-85. doi: 10.1152/ajplung.00015.2015. Epub 2015 Mar 20. Am J Physiol Lung Cell Mol Physiol. 2015. PMID: 25795724 Free PMC article.
191 results