Mitochondrial DNA damage triggers mitochondrial dysfunction and apoptosis in oxidant-challenged lung endothelial cells.
Ruchko M, Gorodnya O, LeDoux SP, Alexeyev MF, Al-Mehdi AB, Gillespie MN.
Ruchko M, et al. Among authors: gillespie mn.
Am J Physiol Lung Cell Mol Physiol. 2005 Mar;288(3):L530-5. doi: 10.1152/ajplung.00255.2004. Epub 2004 Nov 24.
Am J Physiol Lung Cell Mol Physiol. 2005.
PMID: 15563690
Free article.
In pulmonary artery endothelial cells (PAECs), oxidant-mediated damage to mitochondrial DNA (mtDNA) seems to be critical in initiating cytotoxicity inasmuch as overexpression of the mitochondrially targeted human DNA repair enzyme, human Ogg1 (hOgg1), prevents both mtDNA damage a …
In pulmonary artery endothelial cells (PAECs), oxidant-mediated damage to mitochondrial DNA (mtDNA) seems to be critical in initiating cytot …