Xiao Y - Search Results

1

Isolation and characterization of CvIV4: a pain inducing α-scorpion toxin.

Rowe AH, Xiao Y, Scales J, Linse KD, Rowe MP, Cummins TR, Zakon HH. Rowe AH, et al. Among authors: xiao y. PLoS One. 2011;6(8):e23520. doi: 10.1371/journal.pone.0023520. Epub 2011 Aug 24. PLoS One. 2011. PMID: 21887265 Free PMC article.

2

Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration.

Xiao Y, Bingham JP, Zhu W, Moczydlowski E, Liang S, Cummins TR. Xiao Y, et al. J Biol Chem. 2008 Oct 3;283(40):27300-13. doi: 10.1074/jbc.M708447200. Epub 2008 Jul 14. J Biol Chem. 2008. PMID: 18628201 Free PMC article.

3

Alternative splicing of Na(V)1.7 exon 5 increases the impact of the painful PEPD mutant channel I1461T.

Jarecki BW, Sheets PL, Xiao Y, Jackson JO 2nd, Cummins TR. Jarecki BW, et al. Among authors: xiao y. Channels (Austin). 2009 Jul-Aug;3(4):259-67. doi: 10.4161/chan.3.4.9341. Epub 2009 Jul 23. Channels (Austin). 2009. PMID: 19633428 Free PMC article.

4

The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation.

Xiao Y, Blumenthal K, Jackson JO 2nd, Liang S, Cummins TR. Xiao Y, et al. Mol Pharmacol. 2010 Dec;78(6):1124-34. doi: 10.1124/mol.110.066332. Epub 2010 Sep 20. Mol Pharmacol. 2010. PMID: 20855463 Free PMC article.

5

Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV.

Xiao Y, Jackson JO 2nd, Liang S, Cummins TR. Xiao Y, et al. J Biol Chem. 2011 Aug 5;286(31):27301-10. doi: 10.1074/jbc.M111.246876. Epub 2011 Jun 9. J Biol Chem. 2011. PMID: 21659528 Free PMC article.

6

The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity.

Song W, Xiao Y, Chen H, Ashpole NM, Piekarz AD, Ma P, Hudmon A, Cummins TR, Shou W. Song W, et al. Among authors: xiao y. J Physiol. 2012 Oct 15;590(20):5123-39. doi: 10.1113/jphysiol.2012.235374. Epub 2012 Jul 23. J Physiol. 2012. PMID: 22826127 Free PMC article.

7

Structural basis for the modulation of the neuronal voltage-gated sodium channel NaV1.6 by calmodulin.

Reddy Chichili VP, Xiao Y, Seetharaman J, Cummins TR, Sivaraman J. Reddy Chichili VP, et al. Among authors: xiao y. Sci Rep. 2013;3:2435. doi: 10.1038/srep02435. Sci Rep. 2013. PMID: 23942337 Free PMC article.

8

Voltage-gated sodium channel in grasshopper mice defends against bark scorpion toxin.

Rowe AH, Xiao Y, Rowe MP, Cummins TR, Zakon HH. Rowe AH, et al. Among authors: xiao y. Science. 2013 Oct 25;342(6157):441-446. doi: 10.1126/science.1236451. Science. 2013. PMID: 24159039 Free PMC article.

9

Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins.

Xiao Y, Blumenthal K, Cummins TR. Xiao Y, et al. Mol Pharmacol. 2014 Aug;86(2):159-67. doi: 10.1124/mol.114.092338. Epub 2014 Jun 4. Mol Pharmacol. 2014. PMID: 24898004 Free PMC article.

10

Substituted N-(biphenyl-4'-yl)methyl (R)-2-acetamido-3-methoxypropionamides: potent anticonvulsants that affect frequency (use) dependence and slow inactivation of sodium channels.

Lee H, Park KD, Torregrosa R, Yang XF, Dustrude ET, Wang Y, Wilson SM, Barbosa C, Xiao Y, Cummins TR, Khanna R, Kohn H. Lee H, et al. Among authors: xiao y. J Med Chem. 2014 Jul 24;57(14):6165-82. doi: 10.1021/jm500707r. Epub 2014 Jul 15. J Med Chem. 2014. PMID: 25004277 Free PMC article.

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