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A novel murine model of severe pulmonary arterial hypertension.
Ciuclan L, Bonneau O, Hussey M, Duggan N, Holmes AM, Good R, Stringer R, Jones P, Morrell NW, Jarai G, Walker C, Westwick J, Thomas M. Ciuclan L, et al. Among authors: holmes am. Am J Respir Crit Care Med. 2011 Nov 15;184(10):1171-82. doi: 10.1164/rccm.201103-0412OC. Epub 2011 Aug 25. Am J Respir Crit Care Med. 2011. PMID: 21868504
Activin-like kinase 5 (ALK5) mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrotaline.
Thomas M, Docx C, Holmes AM, Beach S, Duggan N, England K, Leblanc C, Lebret C, Schindler F, Raza F, Walker C, Crosby A, Davies RJ, Morrell NW, Budd DC. Thomas M, et al. Among authors: holmes am. Am J Pathol. 2009 Feb;174(2):380-9. doi: 10.2353/ajpath.2009.080565. Epub 2008 Dec 30. Am J Pathol. 2009. PMID: 19116361 Free PMC article.
BMP type II receptor deficiency confers resistance to growth inhibition by TGF-β in pulmonary artery smooth muscle cells: role of proinflammatory cytokines.
Davies RJ, Holmes AM, Deighton J, Long L, Yang X, Barker L, Walker C, Budd DC, Upton PD, Morrell NW. Davies RJ, et al. Among authors: holmes am. Am J Physiol Lung Cell Mol Physiol. 2012 Mar 15;302(6):L604-15. doi: 10.1152/ajplung.00309.2011. Epub 2012 Jan 6. Am J Physiol Lung Cell Mol Physiol. 2012. PMID: 22227206 Free PMC article.
Evidence for the involvement of type I interferon in pulmonary arterial hypertension.
George PM, Oliver E, Dorfmuller P, Dubois OD, Reed DM, Kirkby NS, Mohamed NA, Perros F, Antigny F, Fadel E, Schreiber BE, Holmes AM, Southwood M, Hagan G, Wort SJ, Bartlett N, Morrell NW, Coghlan JG, Humbert M, Zhao L, Mitchell JA. George PM, et al. Among authors: holmes am. Circ Res. 2014 Feb 14;114(4):677-88. doi: 10.1161/CIRCRESAHA.114.302221. Epub 2013 Dec 13. Circ Res. 2014. PMID: 24334027 Free PMC article.
176 results