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SadA, a trimeric autotransporter from Salmonella enterica serovar Typhimurium, can promote biofilm formation and provides limited protection against infection.
Raghunathan D, Wells TJ, Morris FC, Shaw RK, Bobat S, Peters SE, Paterson GK, Jensen KT, Leyton DL, Blair JM, Browning DF, Pravin J, Flores-Langarica A, Hitchcock JR, Moraes CT, Piazza RM, Maskell DJ, Webber MA, May RC, MacLennan CA, Piddock LJ, Cunningham AF, Henderson IR. Raghunathan D, et al. Among authors: pravin j. Infect Immun. 2011 Nov;79(11):4342-52. doi: 10.1128/IAI.05592-11. Epub 2011 Aug 22. Infect Immun. 2011. PMID: 21859856 Free PMC article.
Increased severity of respiratory infections associated with elevated anti-LPS IgG2 which inhibits serum bactericidal killing.
Wells TJ, Whitters D, Sevastsyanovich YR, Heath JN, Pravin J, Goodall M, Browning DF, O'Shea MK, Cranston A, De Soyza A, Cunningham AF, MacLennan CA, Henderson IR, Stockley RA. Wells TJ, et al. Among authors: pravin j. J Exp Med. 2014 Aug 25;211(9):1893-904. doi: 10.1084/jem.20132444. Epub 2014 Aug 11. J Exp Med. 2014. PMID: 25113975 Free PMC article.