Beum PV - Search Results

1

Loss of CD20 and bound CD20 antibody from opsonized B cells occurs more rapidly because of trogocytosis mediated by Fc receptor-expressing effector cells than direct internalization by the B cells.

Beum PV, Peek EM, Lindorfer MA, Beurskens FJ, Engelberts PJ, Parren PW, van de Winkel JG, Taylor RP. Beum PV, et al. J Immunol. 2011 Sep 15;187(6):3438-47. doi: 10.4049/jimmunol.1101189. Epub 2011 Aug 12. J Immunol. 2011. PMID: 21841127

2

Rituximab infusion promotes rapid complement depletion and acute CD20 loss in chronic lymphocytic leukemia.

Kennedy AD, Beum PV, Solga MD, DiLillo DJ, Lindorfer MA, Hess CE, Densmore JJ, Williams ME, Taylor RP. Kennedy AD, et al. Among authors: beum pv. J Immunol. 2004 Mar 1;172(5):3280-8. doi: 10.4049/jimmunol.172.5.3280. J Immunol. 2004. PMID: 14978136

3

Three new assays for rituximab based on its immunological activity or antigenic properties: analyses of sera and plasmas of RTX-treated patients with chronic lymphocytic leukemia and other B cell lymphomas.

Beum PV, Kennedy AD, Taylor RP. Beum PV, et al. J Immunol Methods. 2004 Jun;289(1-2):97-109. doi: 10.1016/j.jim.2004.03.012. J Immunol Methods. 2004. PMID: 15251416

4

The shaving reaction: rituximab/CD20 complexes are removed from mantle cell lymphoma and chronic lymphocytic leukemia cells by THP-1 monocytes.

Beum PV, Kennedy AD, Williams ME, Lindorfer MA, Taylor RP. Beum PV, et al. J Immunol. 2006 Feb 15;176(4):2600-9. doi: 10.4049/jimmunol.176.4.2600. J Immunol. 2006. PMID: 16456022

5

Quantitative analysis of protein co-localization on B cells opsonized with rituximab and complement using the ImageStream multispectral imaging flow cytometer.

Beum PV, Lindorfer MA, Hall BE, George TC, Frost K, Morrissey PJ, Taylor RP. Beum PV, et al. J Immunol Methods. 2006 Dec 20;317(1-2):90-9. doi: 10.1016/j.jim.2006.09.012. Epub 2006 Oct 10. J Immunol Methods. 2006. PMID: 17067631

6

Thrice-weekly low-dose rituximab decreases CD20 loss via shaving and promotes enhanced targeting in chronic lymphocytic leukemia.

Williams ME, Densmore JJ, Pawluczkowycz AW, Beum PV, Kennedy AD, Lindorfer MA, Hamil SH, Eggleton JC, Taylor RP. Williams ME, et al. Among authors: beum pv. J Immunol. 2006 Nov 15;177(10):7435-43. doi: 10.4049/jimmunol.177.10.7435. J Immunol. 2006. PMID: 17082663

7

Complement activation on B lymphocytes opsonized with rituximab or ofatumumab produces substantial changes in membrane structure preceding cell lysis.

Beum PV, Lindorfer MA, Beurskens F, Stukenberg PT, Lokhorst HM, Pawluczkowycz AW, Parren PW, van de Winkel JG, Taylor RP. Beum PV, et al. J Immunol. 2008 Jul 1;181(1):822-32. doi: 10.4049/jimmunol.181.1.822. J Immunol. 2008. PMID: 18566448

8

Within peripheral blood mononuclear cells, antibody-dependent cellular cytotoxicity of rituximab-opsonized Daudi cells is promoted by NK cells and inhibited by monocytes due to shaving.

Beum PV, Lindorfer MA, Taylor RP. Beum PV, et al. J Immunol. 2008 Aug 15;181(4):2916-24. doi: 10.4049/jimmunol.181.4.2916. J Immunol. 2008. PMID: 18684983

9

Binding of rituximab, trastuzumab, cetuximab, or mAb T101 to cancer cells promotes trogocytosis mediated by THP-1 cells and monocytes.

Beum PV, Mack DA, Pawluczkowycz AW, Lindorfer MA, Taylor RP. Beum PV, et al. J Immunol. 2008 Dec 1;181(11):8120-32. doi: 10.4049/jimmunol.181.11.8120. J Immunol. 2008. PMID: 19018005

10

Binding of submaximal C1q promotes complement-dependent cytotoxicity (CDC) of B cells opsonized with anti-CD20 mAbs ofatumumab (OFA) or rituximab (RTX): considerably higher levels of CDC are induced by OFA than by RTX.

Pawluczkowycz AW, Beurskens FJ, Beum PV, Lindorfer MA, van de Winkel JG, Parren PW, Taylor RP. Pawluczkowycz AW, et al. Among authors: beum pv. J Immunol. 2009 Jul 1;183(1):749-58. doi: 10.4049/jimmunol.0900632. Epub 2009 Jun 17. J Immunol. 2009. PMID: 19535640

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