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Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.
Johnen H, Lin S, Kuffner T, Brown DA, Tsai VW, Bauskin AR, Wu L, Pankhurst G, Jiang L, Junankar S, Hunter M, Fairlie WD, Lee NJ, Enriquez RF, Baldock PA, Corey E, Apple FS, Murakami MM, Lin EJ, Wang C, During MJ, Sainsbury A, Herzog H, Breit SN. Johnen H, et al. Nat Med. 2007 Nov;13(11):1333-40. doi: 10.1038/nm1677. Epub 2007 Nov 4. Nat Med. 2007. PMID: 17982462
TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator.
Tsai VW, Macia L, Johnen H, Kuffner T, Manadhar R, Jørgensen SB, Lee-Ng KK, Zhang HP, Wu L, Marquis CP, Jiang L, Husaini Y, Lin S, Herzog H, Brown DA, Sainsbury A, Breit SN. Tsai VW, et al. Among authors: johnen h. PLoS One. 2013;8(2):e55174. doi: 10.1371/journal.pone.0055174. Epub 2013 Feb 28. PLoS One. 2013. PMID: 23468844 Free PMC article.
The propeptide mediates formation of stromal stores of PROMIC-1: role in determining prostate cancer outcome.
Bauskin AR, Brown DA, Junankar S, Rasiah KK, Eggleton S, Hunter M, Liu T, Smith D, Kuffner T, Pankhurst GJ, Johnen H, Russell PJ, Barret W, Stricker PD, Grygiel JJ, Kench JG, Henshall SM, Sutherland RL, Breit SN. Bauskin AR, et al. Among authors: johnen h. Cancer Res. 2005 Mar 15;65(6):2330-6. doi: 10.1158/0008-5472.CAN-04-3827. Cancer Res. 2005. PMID: 15781647
14 results