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N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors.
Désiré J, Mondon M, Fontelle N, Nakagawa S, Hirokami Y, Adachi I, Iwaki R, Fleet GW, Alonzi DS, Twigg G, Butters TD, Bertrand J, Cendret V, Becq F, Norez C, Marrot J, Kato A, Blériot Y. Désiré J, et al. Among authors: butters td. Org Biomol Chem. 2014 Nov 28;12(44):8977-96. doi: 10.1039/c4ob00325j. Org Biomol Chem. 2014. PMID: 25277226
Scalable syntheses of both enantiomers of DNJNAc and DGJNAc from glucuronolactone: the effect of N-alkylation on hexosaminidase inhibition.
Glawar AF, Best D, Ayers BJ, Miyauchi S, Nakagawa S, Aguilar-Moncayo M, García Fernández JM, Ortiz Mellet C, Crabtree EV, Butters TD, Wilson FX, Kato A, Fleet GW. Glawar AF, et al. Among authors: butters td. Chemistry. 2012 Jul 23;18(30):9341-59. doi: 10.1002/chem.201200110. Epub 2012 Jun 26. Chemistry. 2012. PMID: 22736508
Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease.
Brumshtein B, Greenblatt HM, Butters TD, Shaaltiel Y, Aviezer D, Silman I, Futerman AH, Sussman JL. Brumshtein B, et al. Among authors: butters td. J Biol Chem. 2007 Sep 28;282(39):29052-29058. doi: 10.1074/jbc.M705005200. Epub 2007 Jul 31. J Biol Chem. 2007. PMID: 17666401 Free article.
174 results