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Regeneration of the heart in diabetes by selective copper chelation.
Cooper GJ, Phillips AR, Choong SY, Leonard BL, Crossman DJ, Brunton DH, Saafi 'L, Dissanayake AM, Cowan BR, Young AA, Occleshaw CJ, Chan YK, Leahy FE, Keogh GF, Gamble GD, Allen GR, Pope AJ, Boyd PD, Poppitt SD, Borg TK, Doughty RN, Baker JR. Cooper GJ, et al. Diabetes. 2004 Sep;53(9):2501-8. doi: 10.2337/diabetes.53.9.2501. Diabetes. 2004. PMID: 15331567
Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation.
Zhang S, Liu H, Amarsingh GV, Cheung CC, Hogl S, Narayanan U, Zhang L, McHarg S, Xu J, Gong D, Kennedy J, Barry B, Choong YS, Phillips AR, Cooper GJ. Zhang S, et al. Among authors: cooper gj. Cardiovasc Diabetol. 2014 Jun 14;13:100. doi: 10.1186/1475-2840-13-100. Cardiovasc Diabetol. 2014. PMID: 24927960 Free PMC article.
Diabetes-induced alterations in tissue collagen and carboxymethyllysine in rat kidneys: Association with increased collagen-degrading proteinases and amelioration by Cu(II)-selective chelation.
Brings S, Zhang S, Choong YS, Hogl S, Middleditch M, Kamalov M, Brimble MA, Gong D, Cooper GJ. Brings S, et al. Among authors: cooper gj. Biochim Biophys Acta. 2015 Aug;1852(8):1610-8. doi: 10.1016/j.bbadis.2015.04.014. Epub 2015 Apr 18. Biochim Biophys Acta. 2015. PMID: 25900786 Free article.
Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer's disease: metabolic basis for dementia.
Xu J, Begley P, Church SJ, Patassini S, McHarg S, Kureishy N, Hollywood KA, Waldvogel HJ, Liu H, Zhang S, Lin W, Herholz K, Turner C, Synek BJ, Curtis MA, Rivers-Auty J, Lawrence CB, Kellett KA, Hooper NM, Vardy ER, Wu D, Unwin RD, Faull RL, Dowsey AW, Cooper GJ. Xu J, et al. Among authors: cooper gj. Sci Rep. 2016 Jun 9;6:27524. doi: 10.1038/srep27524. Sci Rep. 2016. PMID: 27276998 Free PMC article.
Amylin, amyloid and age-related disease.
Cooper GJ, Tse CA. Cooper GJ, et al. Drugs Aging. 1996 Sep;9(3):202-12. doi: 10.2165/00002512-199609030-00006. Drugs Aging. 1996. PMID: 8877314 Review.
Demonstration of a hyperglycemia-driven pathogenic abnormality of copper homeostasis in diabetes and its reversibility by selective chelation: quantitative comparisons between the biology of copper and eight other nutritionally essential elements in normal and diabetic individuals.
Cooper GJ, Chan YK, Dissanayake AM, Leahy FE, Keogh GF, Frampton CM, Gamble GD, Brunton DH, Baker JR, Poppitt SD. Cooper GJ, et al. Diabetes. 2005 May;54(5):1468-76. doi: 10.2337/diabetes.54.5.1468. Diabetes. 2005. PMID: 15855335
400 results