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How current understanding of clearance mechanisms and pharmacodynamics of therapeutic proteins can be applied for evaluation of their drug-drug interaction potential.
Kraynov E, Martin SW, Hurst S, Fahmi OA, Dowty M, Cronenberger C, Loi CM, Kuang B, Fields O, Fountain S, Awwad M, Wang D. Kraynov E, et al. Among authors: fountain s. Drug Metab Dispos. 2011 Oct;39(10):1779-83. doi: 10.1124/dmd.111.040808. Epub 2011 Jul 18. Drug Metab Dispos. 2011. PMID: 21768274 Review.
Tissue bioanalysis of biotherapeutics and drug targets to support PK/PD.
Neubert H, Fountain S, King L, Clark T, Weng Y, O'Hara DM, Li W, Leung S, Ray C, Palandra J, Ocaña MF, Chen J, Ji C, Wang M, Long K, Gorovits B, Fluhler E. Neubert H, et al. Among authors: fountain s. Bioanalysis. 2012 Nov;4(21):2589-604. doi: 10.4155/bio.12.234. Bioanalysis. 2012. PMID: 23173794 Review.
A validated LC/MS/MS method for the quantification of pyrrole-2,3,5-tricarboxylic acid (PTCA), a eumelanin specific biomarker, in human skin punch biopsies.
Szekely-Klepser G, Wade K, Woolson D, Brown R, Fountain S, Kindt E. Szekely-Klepser G, et al. Among authors: fountain s. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Nov 5;826(1-2):31-40. doi: 10.1016/j.jchromb.2005.08.002. Epub 2005 Aug 31. J Chromatogr B Analyt Technol Biomed Life Sci. 2005. PMID: 16139575
177 results