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WNT5B drives osteosarcoma stemness, chemoresistance and metastasis.
Perkins RS, Murray G, Suthon S, Davis L, Perkins NB 3rd, Fletcher L, Bozzi A, Schreiber SL, Lin J, Laxton S, Pillai RR, Wright AJ, Miranda-Carboni GA, Krum SA. Perkins RS, et al. Among authors: schreiber sl. Clin Transl Med. 2024 May;14(5):e1670. doi: 10.1002/ctm2.1670. Clin Transl Med. 2024. PMID: 38689429 Free PMC article.
Bicyclic pyrrolidine inhibitors of Toxoplasma gondii phenylalanine t-RNA synthetase with antiparasitic potency in vitro and brain exposure.
Ence CC, Uddin T, Borrel J, Mittal P, Xie H, Zoller J, Sharma A, Comer E, Schreiber SL, Melillo B, Sibley LD, Chatterjee AK. Ence CC, et al. Among authors: schreiber sl. bioRxiv [Preprint]. 2024 Feb 28:2024.02.28.582607. doi: 10.1101/2024.02.28.582607. bioRxiv. 2024. PMID: 38464220 Free PMC article. Updated. Preprint.
Highly specific intracellular ubiquitination of a small molecule.
Li W, Garcia-Rivera EM, Mitchell DC, Chick JM, Maetani M, Knapp JM, Matthews GM, Shirasaki R, de Matos Simoes R, Viswanathan V, Pulice JL, Rees MG, Roth JA, Gygi SP, Mitsiades CS, Kadoch C, Schreiber SL, Ostrem JML. Li W, et al. Among authors: schreiber sl. bioRxiv [Preprint]. 2024 Jan 28:2024.01.26.577493. doi: 10.1101/2024.01.26.577493. bioRxiv. 2024. PMID: 38328167 Free PMC article. Preprint.
Author Correction: Diversity-oriented synthesis encoded by deoxyoligonucleotides.
Hudson L, Mason JW, Westphal MV, Richter MJR, Thielman JR, Hua BK, Gerry CJ, Xia G, Osswald HL, Knapp JM, Tan ZY, Kokkonda P, Tresco BIC, Liu S, Reidenbach AG, Lim KS, Poirier J, Capece J, Bonazzi S, Gampe CM, Smith NJ, Bradner JE, Coley CW, Clemons PA, Melillo B, Hon CS, Ottl J, Dumelin CE, Schaefer JV, Faust AME, Berst F, Schreiber SL, Zécri FJ, Briner K. Hudson L, et al. Among authors: schreiber sl. Nat Commun. 2023 Nov 21;14(1):7589. doi: 10.1038/s41467-023-43518-2. Nat Commun. 2023. PMID: 37989745 Free PMC article. No abstract available.
DNA-encoded library-enabled discovery of proximity-inducing small molecules.
Mason JW, Chow YT, Hudson L, Tutter A, Michaud G, Westphal MV, Shu W, Ma X, Tan ZY, Coley CW, Clemons PA, Bonazzi S, Berst F, Briner K, Liu S, Zécri FJ, Schreiber SL. Mason JW, et al. Among authors: schreiber sl. Nat Chem Biol. 2024 Feb;20(2):170-179. doi: 10.1038/s41589-023-01458-4. Epub 2023 Nov 2. Nat Chem Biol. 2024. PMID: 37919549
552 results