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Allosteric modulation of β-cell M3 muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese mice.
Zhu L, Rossi M, Cohen A, Pham J, Zheng H, Dattaroy D, Mukaibo T, Melvin JE, Langel JL, Hattar S, Matschinsky FM, Appella DH, Doliba NM, Wess J. Zhu L, et al. Among authors: matschinsky fm. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18684-18690. doi: 10.1073/pnas.1904943116. Epub 2019 Aug 26. Proc Natl Acad Sci U S A. 2019. PMID: 31451647 Free PMC article.
Pdx1 maintains β cell identity and function by repressing an α cell program.
Gao T, McKenna B, Li C, Reichert M, Nguyen J, Singh T, Yang C, Pannikar A, Doliba N, Zhang T, Stoffers DA, Edlund H, Matschinsky F, Stein R, Stanger BZ. Gao T, et al. Among authors: matschinsky f. Cell Metab. 2014 Feb 4;19(2):259-71. doi: 10.1016/j.cmet.2013.12.002. Cell Metab. 2014. PMID: 24506867 Free PMC article.
290 results