Turchi JJ - Search Results

1

Identification of Mre11 as a target for heat radiosensitization.

Dynlacht JR, Batuello CN, Lopez JT, Kim KK, Turchi JJ. Dynlacht JR, et al. Among authors: turchi jj. Radiat Res. 2011 Sep;176(3):323-32. doi: 10.1667/rr2594.1. Epub 2011 Jun 23. Radiat Res. 2011. PMID: 21699368 Free PMC article.

2

Characterization of Thermally Activated Metalloenediyne Cytotoxicity in Human Melanoma Cells.

Keller EJ, Porter M, Garrett JE, Varie M, Wang H, Pollok KE, Turchi JJ, Zaleski JM, Dynlacht JR. Keller EJ, et al. Among authors: turchi jj. Radiat Res. 2018 Aug;190(2):107-116. doi: 10.1667/RR15019.1. Epub 2018 May 15. Radiat Res. 2018. PMID: 29763378 Free PMC article.

3

Discovery and development of novel DNA-PK inhibitors by targeting the unique Ku-DNA interaction.

Gavande NS, VanderVere-Carozza PS, Pawelczak KS, Mendoza-Munoz P, Vernon TL, Hanakahi LA, Summerlin M, Dynlacht JR, Farmer AH, Sears CR, Nasrallah NA, Garrett J, Turchi JJ. Gavande NS, et al. Among authors: turchi jj. Nucleic Acids Res. 2020 Nov 18;48(20):11536-11550. doi: 10.1093/nar/gkaa934. Nucleic Acids Res. 2020. PMID: 33119767 Free PMC article.

4

Characterization and initial demonstration of in vivo efficacy of a novel heat-activated metalloenediyne anti-cancer agent.

Garrett J, Metzger E, Dewhirst MW, Pollok KE, Turchi JJ, Le Poole IC, Couch K, Lew L, Sinn A, Zaleski JM, Dynlacht JR. Garrett J, et al. Among authors: turchi jj. Int J Hyperthermia. 2022;39(1):405-413. doi: 10.1080/02656736.2021.2024280. Int J Hyperthermia. 2022. PMID: 35236209 Free PMC article.

5

Ku-DNA binding inhibitors modulate the DNA damage response in response to DNA double-strand breaks.

Mendoza-Munoz PL, Gavande NS, VanderVere-Carozza PS, Pawelczak KS, Dynlacht JR, Garrett JE, Turchi JJ. Mendoza-Munoz PL, et al. Among authors: turchi jj. NAR Cancer. 2023 Feb 6;5(1):zcad003. doi: 10.1093/narcan/zcad003. eCollection 2023 Mar. NAR Cancer. 2023. PMID: 36755959 Free PMC article.

6

A mechanism for DNA-PK activation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining.

Pawelczak KS, Turchi JJ. Pawelczak KS, et al. Among authors: turchi jj. Nucleic Acids Res. 2008 Jul;36(12):4022-31. doi: 10.1093/nar/gkn344. Epub 2008 May 31. Nucleic Acids Res. 2008. PMID: 18515838 Free PMC article.

7

Molecular analysis of Ku redox regulation.

Bennett SM, Neher TM, Shatilla A, Turchi JJ. Bennett SM, et al. Among authors: turchi jj. BMC Mol Biol. 2009 Aug 28;10:86. doi: 10.1186/1471-2199-10-86. BMC Mol Biol. 2009. PMID: 19715578 Free PMC article.

8

Targeted inhibition of Replication Protein A reveals cytotoxic activity, synergy with chemotherapeutic DNA-damaging agents, and insight into cellular function.

Shuck SC, Turchi JJ. Shuck SC, et al. Among authors: turchi jj. Cancer Res. 2010 Apr 15;70(8):3189-98. doi: 10.1158/0008-5472.CAN-09-3422. Cancer Res. 2010. PMID: 20395205 Free PMC article.

9

Complex cisplatin-double strand break (DSB) lesions directly impair cellular non-homologous end-joining (NHEJ) independent of downstream damage response (DDR) pathways.

Sears CR, Turchi JJ. Sears CR, et al. Among authors: turchi jj. J Biol Chem. 2012 Jul 13;287(29):24263-72. doi: 10.1074/jbc.M112.344911. Epub 2012 May 23. J Biol Chem. 2012. PMID: 22621925 Free PMC article.

10

DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer.

Sears CR, Cooney SA, Chin-Sinex H, Mendonca MS, Turchi JJ. Sears CR, et al. Among authors: turchi jj. DNA Repair (Amst). 2016 Apr;40:35-46. doi: 10.1016/j.dnarep.2016.02.004. Epub 2016 Mar 3. DNA Repair (Amst). 2016. PMID: 26991853 Free PMC article.

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