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The second-generation active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects.
Wiessner C, Wiederhold KH, Tissot AC, Frey P, Danner S, Jacobson LH, Jennings GT, Lüönd R, Ortmann R, Reichwald J, Zurini M, Mir A, Bachmann MF, Staufenbiel M. Wiessner C, et al. Among authors: frey p. J Neurosci. 2011 Jun 22;31(25):9323-31. doi: 10.1523/JNEUROSCI.0293-11.2011. J Neurosci. 2011. PMID: 21697382 Free PMC article.
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology.
Sturchler-Pierrat C, Abramowski D, Duke M, Wiederhold KH, Mistl C, Rothacher S, Ledermann B, Bürki K, Frey P, Paganetti PA, Waridel C, Calhoun ME, Jucker M, Probst A, Staufenbiel M, Sommer B. Sturchler-Pierrat C, et al. Among authors: frey p. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13287-92. doi: 10.1073/pnas.94.24.13287. Proc Natl Acad Sci U S A. 1997. PMID: 9371838 Free PMC article.
Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host.
Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret JM, Paganetti P, Walsh DM, Mathews PM, Ghiso J, Staufenbiel M, Walker LC, Jucker M. Meyer-Luehmann M, et al. Among authors: frey p. Science. 2006 Sep 22;313(5794):1781-4. doi: 10.1126/science.1131864. Science. 2006. PMID: 16990547
Distinct processing of endogenous and overexpressed recombinant presenilin 1.
Baumann K, Paganetti PA, Sturchler-Pierrat C, Wong C, Hartmann H, Cescato R, Frey P, Yankner BA, Sommer B, Staufenbiel M. Baumann K, et al. Among authors: frey p. Neurobiol Aging. 1997 Mar-Apr;18(2):181-9. doi: 10.1016/s0197-4580(97)00004-3. Neurobiol Aging. 1997. PMID: 9258895
582 results