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Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates.
Becker-Pauly C, Barré O, Schilling O, Auf dem Keller U, Ohler A, Broder C, Schütte A, Kappelhoff R, Stöcker W, Overall CM. Becker-Pauly C, et al. Among authors: stocker w. Mol Cell Proteomics. 2011 Sep;10(9):M111.009233. doi: 10.1074/mcp.M111.009233. Epub 2011 Jun 21. Mol Cell Proteomics. 2011. PMID: 21693781 Free PMC article.
Activation mechanism of pro-astacin: role of the pro-peptide, tryptic and autoproteolytic cleavage and importance of precise amino-terminal processing.
Yiallouros I, Kappelhoff R, Schilling O, Wegmann F, Helms MW, Auge A, Brachtendorf G, Berkhoff EG, Beermann B, Hinz HJ, König S, Peter-Katalinic J, Stöcker W. Yiallouros I, et al. Among authors: stocker w. J Mol Biol. 2002 Nov 22;324(2):237-46. doi: 10.1016/s0022-2836(02)01102-6. J Mol Biol. 2002. PMID: 12441103
The interaction of recombinant subdomains of the procollagen C-proteinase with procollagen I provides a quantitative explanation for functional differences between the two splice variants, mammalian tolloid and bone morphogenetic protein 1.
Hintze V, Höwel M, Wermter C, Grosse Berkhoff E, Becker-Pauly C, Beermann B, Yiallouros I, Stöcker W. Hintze V, et al. Among authors: stocker w. Biochemistry. 2006 May 30;45(21):6741-8. doi: 10.1021/bi060228k. Biochemistry. 2006. PMID: 16716085
The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation.
Becker-Pauly C, Höwel M, Walker T, Vlad A, Aufenvenne K, Oji V, Lottaz D, Sterchi EE, Debela M, Magdolen V, Traupe H, Stöcker W. Becker-Pauly C, et al. Among authors: stocker w. J Invest Dermatol. 2007 May;127(5):1115-25. doi: 10.1038/sj.jid.5700675. Epub 2007 Jan 4. J Invest Dermatol. 2007. PMID: 17195012 Free article.
Proenzyme structure and activation of astacin metallopeptidase.
Guevara T, Yiallouros I, Kappelhoff R, Bissdorf S, Stöcker W, Gomis-Rüth FX. Guevara T, et al. Among authors: stocker w. J Biol Chem. 2010 Apr 30;285(18):13958-65. doi: 10.1074/jbc.M109.097436. Epub 2010 Mar 4. J Biol Chem. 2010. PMID: 20202938 Free PMC article.
243 results