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Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates.
Becker-Pauly C, Barré O, Schilling O, Auf dem Keller U, Ohler A, Broder C, Schütte A, Kappelhoff R, Stöcker W, Overall CM. Becker-Pauly C, et al. Among authors: schilling o. Mol Cell Proteomics. 2011 Sep;10(9):M111.009233. doi: 10.1074/mcp.M111.009233. Epub 2011 Jun 21. Mol Cell Proteomics. 2011. PMID: 21693781 Free PMC article.
Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses.
Eckhard U, Huesgen PF, Schilling O, Bellac CL, Butler GS, Cox JH, Dufour A, Goebeler V, Kappelhoff R, Keller UAD, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, Rodriguez D, Starr AE, Wang Y, Overall CM. Eckhard U, et al. Among authors: schilling o. Matrix Biol. 2016 Jan;49:37-60. doi: 10.1016/j.matbio.2015.09.003. Epub 2015 Sep 25. Matrix Biol. 2016. PMID: 26407638 Free article.
Proteomic discovery of protease substrates.
Schilling O, Overall CM. Schilling O, et al. Curr Opin Chem Biol. 2007 Feb;11(1):36-45. doi: 10.1016/j.cbpa.2006.11.037. Epub 2006 Dec 27. Curr Opin Chem Biol. 2007. PMID: 17194619 Review.
Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo.
Jefferson T, Čaušević M, auf dem Keller U, Schilling O, Isbert S, Geyer R, Maier W, Tschickardt S, Jumpertz T, Weggen S, Bond JS, Overall CM, Pietrzik CU, Becker-Pauly C. Jefferson T, et al. Among authors: schilling o. J Biol Chem. 2011 Aug 5;286(31):27741-50. doi: 10.1074/jbc.M111.252718. Epub 2011 Jun 6. J Biol Chem. 2011. PMID: 21646356 Free PMC article.
267 results