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Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates.
Becker-Pauly C, Barré O, Schilling O, Auf dem Keller U, Ohler A, Broder C, Schütte A, Kappelhoff R, Stöcker W, Overall CM. Becker-Pauly C, et al. Among authors: ohler a. Mol Cell Proteomics. 2011 Sep;10(9):M111.009233. doi: 10.1074/mcp.M111.009233. Epub 2011 Jun 21. Mol Cell Proteomics. 2011. PMID: 21693781 Free PMC article.
The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.
Jefferson T, Auf dem Keller U, Bellac C, Metz VV, Broder C, Hedrich J, Ohler A, Maier W, Magdolen V, Sterchi E, Bond JS, Jayakumar A, Traupe H, Chalaris A, Rose-John S, Pietrzik CU, Postina R, Overall CM, Becker-Pauly C. Jefferson T, et al. Among authors: ohler a. Cell Mol Life Sci. 2013 Jan;70(2):309-33. doi: 10.1007/s00018-012-1106-2. Epub 2012 Sep 1. Cell Mol Life Sci. 2013. PMID: 22940918 Free PMC article.
Meprin β: A novel regulator of blood-brain barrier integrity.
Gindorf M, Storck SE, Ohler A, Scharfenberg F, Becker-Pauly C, Pietrzik CU. Gindorf M, et al. Among authors: ohler a. J Cereb Blood Flow Metab. 2021 Jan;41(1):31-44. doi: 10.1177/0271678X20905206. Epub 2020 Feb 16. J Cereb Blood Flow Metab. 2021. PMID: 32065075 Free PMC article.
Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin β and promotes transendothelial cell migration.
Bedau T, Peters F, Prox J, Arnold P, Schmidt F, Finkernagel M, Köllmann S, Wichert R, Otte A, Ohler A, Stirnberg M, Lucius R, Koudelka T, Tholey A, Biasin V, Pietrzik CU, Kwapiszewska G, Becker-Pauly C. Bedau T, et al. Among authors: ohler a. FASEB J. 2017 Mar;31(3):1226-1237. doi: 10.1096/fj.201601113R. Epub 2016 Dec 21. FASEB J. 2017. PMID: 28003343
Accordingly, deficiency of meprin beta in Mep1b(-/-) mice resulted in significantly increased CD99 protein levels in the lung. Therefore, meprin beta could serve as a therapeutic target, given that in a proof-of-concept approach we showed accumulation of CD99 protei …
Accordingly, deficiency of meprin beta in Mep1b(-/-) mice resulted in significantly increased CD99 protein levels in the lung. Therefore, me …
74 results