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Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis.
Fukata M, Shang L, Santaolalla R, Sotolongo J, Pastorini C, España C, Ungaro R, Harpaz N, Cooper HS, Elson G, Kosco-Vilbois M, Zaias J, Perez MT, Mayer L, Vamadevan AS, Lira SA, Abreu MT. Fukata M, et al. Among authors: santaolalla r. Inflamm Bowel Dis. 2011 Jul;17(7):1464-73. doi: 10.1002/ibd.21527. Epub 2010 Nov 15. Inflamm Bowel Dis. 2011. PMID: 21674704 Free PMC article.
TLR4 activates the β-catenin pathway to cause intestinal neoplasia.
Santaolalla R, Sussman DA, Ruiz JR, Davies JM, Pastorini C, España CL, Sotolongo J, Burlingame O, Bejarano PA, Philip S, Ahmed MM, Ko J, Dirisina R, Barrett TA, Shang L, Lira SA, Fukata M, Abreu MT. Santaolalla R, et al. PLoS One. 2013 May 14;8(5):e63298. doi: 10.1371/journal.pone.0063298. Print 2013. PLoS One. 2013. PMID: 23691015 Free PMC article.
Innate immunity in the small intestine.
Santaolalla R, Fukata M, Abreu MT. Santaolalla R, et al. Curr Opin Gastroenterol. 2011 Mar;27(2):125-31. doi: 10.1097/MOG.0b013e3283438dea. Curr Opin Gastroenterol. 2011. PMID: 21248635 Free PMC article. Review.
Innate immunity in the small intestine.
Santaolalla R, Abreu MT. Santaolalla R, et al. Curr Opin Gastroenterol. 2012 Mar;28(2):124-9. doi: 10.1097/MOG.0b013e3283506559. Curr Opin Gastroenterol. 2012. PMID: 22241076 Free PMC article. Review.
Cancer in inflammatory bowel disease: lessons from animal models.
Sussman DA, Santaolalla R, Strobel S, Dheer R, Abreu MT. Sussman DA, et al. Among authors: santaolalla r. Curr Opin Gastroenterol. 2012 Jul;28(4):327-33. doi: 10.1097/MOG.0b013e328354cc36. Curr Opin Gastroenterol. 2012. PMID: 22614440 Free PMC article. Review.
Epithelial TLR4 Signaling Activates DUOX2 to Induce Microbiota-Driven Tumorigenesis.
Burgueño JF, Fritsch J, González EE, Landau KS, Santander AM, Fernández I, Hazime H, Davies JM, Santaolalla R, Phillips MC, Diaz S, Dheer R, Brito N, Pignac-Kobinger J, Fernández E, Conner GE, Abreu MT. Burgueño JF, et al. Among authors: santaolalla r. Gastroenterology. 2021 Feb;160(3):797-808.e6. doi: 10.1053/j.gastro.2020.10.031. Epub 2020 Oct 24. Gastroenterology. 2021. PMID: 33127391 Free PMC article.
22 results