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Page 1
Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist.
Benned-Jensen T, Smethurst C, Holst PJ, Page KR, Sauls H, Sivertsen B, Schwartz TW, Blanchard A, Jepras R, Rosenkilde MM. Benned-Jensen T, et al. Among authors: smethurst c. J Biol Chem. 2011 Aug 19;286(33):29292-29302. doi: 10.1074/jbc.M110.196345. Epub 2011 Jun 14. J Biol Chem. 2011. PMID: 21673108 Free PMC article.
Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses.
Demont EH, Bailey JM, Bit RA, Brown JA, Campbell CA, Deeks N, Dowell SJ, Eldred C, Gaskin P, Gray JR, Haynes A, Hirst DJ, Holmes DS, Kumar U, Morse MA, Osborne GJ, Renaux JF, Seal GA, Smethurst CA, Taylor S, Watson R, Willis R, Witherington J. Demont EH, et al. Among authors: smethurst ca. J Med Chem. 2016 Feb 11;59(3):1003-20. doi: 10.1021/acs.jmedchem.5b01512. Epub 2016 Jan 22. J Med Chem. 2016. PMID: 26751273
Identification of a sulfonamide series of CCR2 antagonists.
Peace S, Philp J, Brooks C, Piercy V, Moores K, Smethurst C, Watson S, Gaines S, Zippoli M, Mookherjee C, Ife R. Peace S, et al. Among authors: smethurst c. Bioorg Med Chem Lett. 2010 Jul 1;20(13):3961-4. doi: 10.1016/j.bmcl.2010.04.142. Epub 2010 May 7. Bioorg Med Chem Lett. 2010. PMID: 20627722
In vivo activity of an azole series of CCR2 antagonists.
Smethurst CA, Bevan N, Brooks C, Emmons A, Gough PJ, Mookherjee C, Moores K, Peace S, Philp J, Piercy V, Watson SP, Zippoli M. Smethurst CA, et al. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7252-5. doi: 10.1016/j.bmcl.2012.09.020. Epub 2012 Sep 23. Bioorg Med Chem Lett. 2012. PMID: 23079519
The characterization of a novel V1b antagonist lead series.
Smethurst CA, Borthwick JA, Gaines S, Watson S, Green A, Schulz MJ, Burton G, Buson AA, Arban R. Smethurst CA, et al. Bioorg Med Chem Lett. 2011 Jan 1;21(1):92-6. doi: 10.1016/j.bmcl.2010.11.061. Epub 2010 Nov 19. Bioorg Med Chem Lett. 2011. PMID: 21146408
New Selenium-Based Safety-Catch Linkers: Solid-Phase Semisynthesis of Vancomycin We thank Drs. D. H. Huang and G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), The Skaggs Institute for Chemical Biology, a fellowship from the George Hewitt Foundation (N. W.), and grants from Schering Plough, Pfizer, Glaxo, Merck, Hoffmann-La Roche, DuPont, and Abbott Laboratories.
Nicolaou KC, Winssinger N, Hughes R, Smethurst C, Cho SY. Nicolaou KC, et al. Among authors: smethurst c. Angew Chem Int Ed Engl. 2000 Mar;39(6):1084-1088. doi: 10.1002/(sici)1521-3773(20000317)39:6<1084::aid-anie1084>3.0.co;2-o. Angew Chem Int Ed Engl. 2000. PMID: 10760929 No abstract available.
Target-Accelerated Combinatorial Synthesis and Discovery of Highly Potent Antibiotics Effective Against Vancomycin-Resistant Bacteria.
Nicolaou KC, Hughes R, Cho SY, Winssinger N, Smethurst C, Labischinski H, Endermann R. Nicolaou KC, et al. Among authors: smethurst c. Angew Chem Int Ed Engl. 2000 Nov 3;39(21):3823-3828. doi: 10.1002/1521-3773(20001103)39:21<3823::AID-ANIE3823>3.0.CO;2-3. Angew Chem Int Ed Engl. 2000. PMID: 29711708 No abstract available.
21 results