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Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist.
Benned-Jensen T, Smethurst C, Holst PJ, Page KR, Sauls H, Sivertsen B, Schwartz TW, Blanchard A, Jepras R, Rosenkilde MM. Benned-Jensen T, et al. Among authors: sauls h. J Biol Chem. 2011 Aug 19;286(33):29292-29302. doi: 10.1074/jbc.M110.196345. Epub 2011 Jun 14. J Biol Chem. 2011. PMID: 21673108 Free PMC article.
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.
Briscoe CP, Tadayyon M, Andrews JL, Benson WG, Chambers JK, Eilert MM, Ellis C, Elshourbagy NA, Goetz AS, Minnick DT, Murdock PR, Sauls HR Jr, Shabon U, Spinage LD, Strum JC, Szekeres PG, Tan KB, Way JM, Ignar DM, Wilson S, Muir AI. Briscoe CP, et al. Among authors: sauls hr jr. J Biol Chem. 2003 Mar 28;278(13):11303-11. doi: 10.1074/jbc.M211495200. Epub 2002 Dec 19. J Biol Chem. 2003. PMID: 12496284 Free article.
2,5-Disubstituted pyridines as potent GPR119 agonists.
Wu Y, Kuntz JD, Carpenter AJ, Fang J, Sauls HR, Gomez DJ, Ammala C, Xu Y, Hart S, Tadepalli S. Wu Y, et al. Among authors: sauls hr. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2577-81. doi: 10.1016/j.bmcl.2010.02.083. Epub 2010 Feb 25. Bioorg Med Chem Lett. 2010. PMID: 20227877
Discovery of 6,7-dihydro-5H-pyrrolo[2,3-a]pyrimidines as orally available G protein-coupled receptor 119 agonists.
Katamreddy SR, Carpenter AJ, Ammala CE, Boros EE, Brashear RL, Briscoe CP, Bullard SR, Caldwell RD, Conlee CR, Croom DK, Hart SM, Heyer DO, Johnson PR, Kashatus JA, Minick DJ, Peckham GE, Ross SA, Roller SG, Samano VA, Sauls HR, Tadepalli SM, Thompson JB, Xu Y, Way JM. Katamreddy SR, et al. Among authors: sauls hr. J Med Chem. 2012 Dec 27;55(24):10972-94. doi: 10.1021/jm301404a. Epub 2012 Dec 12. J Med Chem. 2012. PMID: 23214471
Functional screening in the melanophore bioassay.
Jayawickreme C, Sauls H, Watson C, Moncol D, Rimele T, Kenakin T. Jayawickreme C, et al. Among authors: sauls h. Curr Protoc Pharmacol. 2005 Jul;Chapter 12:Unit12.9. doi: 10.1002/0471141755.ph1209s29. Curr Protoc Pharmacol. 2005. PMID: 21953388
14 results