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735 results

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Page 1
Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist.
Benned-Jensen T, Smethurst C, Holst PJ, Page KR, Sauls H, Sivertsen B, Schwartz TW, Blanchard A, Jepras R, Rosenkilde MM. Benned-Jensen T, et al. Among authors: blanchard a. J Biol Chem. 2011 Aug 19;286(33):29292-29302. doi: 10.1074/jbc.M110.196345. Epub 2011 Jun 14. J Biol Chem. 2011. PMID: 21673108 Free PMC article.
Novel insights into the function and dynamics of extracellular matrix in liver fibrosis.
Karsdal MA, Manon-Jensen T, Genovese F, Kristensen JH, Nielsen MJ, Sand JM, Hansen NU, Bay-Jensen AC, Bager CL, Krag A, Blanchard A, Krarup H, Leeming DJ, Schuppan D. Karsdal MA, et al. Among authors: blanchard a. Am J Physiol Gastrointest Liver Physiol. 2015 May 15;308(10):G807-30. doi: 10.1152/ajpgi.00447.2014. Epub 2015 Mar 12. Am J Physiol Gastrointest Liver Physiol. 2015. PMID: 25767261 Free PMC article. Review.
mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis.
Selvarajah B, Azuelos I, Platé M, Guillotin D, Forty EJ, Contento G, Woodcock HV, Redding M, Taylor A, Brunori G, Durrenberger PF, Ronzoni R, Blanchard AD, Mercer PF, Anastasiou D, Chambers RC. Selvarajah B, et al. Among authors: blanchard ad. Sci Signal. 2019 May 21;12(582):eaav3048. doi: 10.1126/scisignal.aav3048. Sci Signal. 2019. PMID: 31113850 Free PMC article.
c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis.
Leslie J, Macia MG, Luli S, Worrell JC, Reilly WJ, Paish HL, Knox A, Barksby BS, Gee LM, Zaki MYW, Collins AL, Burgoyne RA, Cameron R, Bragg C, Xu X, Chung GW, Brown CDA, Blanchard AD, Nanthakumar CB, Karsdal M, Robinson SM, Manas DM, Sen G, French J, White SA, Murphy S, Trost M, Zakrzewski JL, Klein U, Schwabe RF, Mederacke I, Nixon C, Bird T, Teuwen LA, Schoonjans L, Carmeliet P, Mann J, Fisher AJ, Sheerin NS, Borthwick LA, Mann DA, Oakley F. Leslie J, et al. Among authors: blanchard ad. Nat Metab. 2020 Nov;2(11):1350-1367. doi: 10.1038/s42255-020-00306-2. Epub 2020 Nov 9. Nat Metab. 2020. PMID: 33168981 Free PMC article.
Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF.
Mercer PF, Woodcock HV, Eley JD, Platé M, Sulikowski MG, Durrenberger PF, Franklin L, Nanthakumar CB, Man Y, Genovese F, McAnulty RJ, Yang S, Maher TM, Nicholson AG, Blanchard AD, Marshall RP, Lukey PT, Chambers RC. Mercer PF, et al. Thorax. 2016 Aug;71(8):701-11. doi: 10.1136/thoraxjnl-2015-207429. Epub 2016 Apr 21. Thorax. 2016. PMID: 27103349 Free PMC article.
The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis.
Woodcock HV, Eley JD, Guillotin D, Platé M, Nanthakumar CB, Martufi M, Peace S, Joberty G, Poeckel D, Good RB, Taylor AR, Zinn N, Redding M, Forty EJ, Hynds RE, Swanton C, Karsdal M, Maher TM, Fisher A, Bergamini G, Marshall RP, Blanchard AD, Mercer PF, Chambers RC. Woodcock HV, et al. Among authors: blanchard ad. Nat Commun. 2019 Jan 2;10(1):6. doi: 10.1038/s41467-018-07858-8. Nat Commun. 2019. PMID: 30602778 Free PMC article.
735 results