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The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis.
Frith JC, Mönkkönen J, Auriola S, Mönkkönen H, Rogers MJ. Frith JC, et al. Among authors: monkkonen j, monkkonen h. Arthritis Rheum. 2001 Sep;44(9):2201-10. doi: 10.1002/1529-0131(200109)44:9<2201::aid-art374>3.0.co;2-e. Arthritis Rheum. 2001. PMID: 11592386 Free article.
A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates.
Mönkkönen H, Auriola S, Lehenkari P, Kellinsalmi M, Hassinen IE, Vepsäläinen J, Mönkkönen J. Mönkkönen H, et al. Among authors: monkkonen j. Br J Pharmacol. 2006 Feb;147(4):437-45. doi: 10.1038/sj.bjp.0706628. Br J Pharmacol. 2006. PMID: 16402039 Free PMC article.
Zoledronic acid-induced IPP/ApppI production in vivo.
Mönkkönen H, Ottewell PD, Kuokkanen J, Mönkkönen J, Auriola S, Holen I. Mönkkönen H, et al. Among authors: monkkonen j. Life Sci. 2007 Sep 8;81(13):1066-70. doi: 10.1016/j.lfs.2007.08.007. Epub 2007 Aug 17. Life Sci. 2007. PMID: 17850825
Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry.
Jauhiainen M, Mönkkönen H, Räikkönen J, Mönkkönen J, Auriola S. Jauhiainen M, et al. Among authors: monkkonen j, monkkonen h. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 1;877(27):2967-75. doi: 10.1016/j.jchromb.2009.07.010. Epub 2009 Jul 14. J Chromatogr B Analyt Technol Biomed Life Sci. 2009. PMID: 19665949
121 results