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The Parallel Structure-Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands.
Ericson MD, Freeman KT, LaVoi TM, Donow HM, Santos RG, Giulianotti MA, Pinilla C, Houghten RA, Haskell-Luevano C. Ericson MD, et al. Among authors: houghten ra. Int J Mol Sci. 2023 Jun 14;24(12):10145. doi: 10.3390/ijms241210145. Int J Mol Sci. 2023. PMID: 37373293 Free PMC article.
Correction to "Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High Throughput 'Unbiased' Screening Campaign".
Doering SR, Freeman K, Debevec G, Geer P, Santos RG, Lavoi TM, Giulianotti MA, Pinilla C, Appel JR, Houghten RA, Ericson MD, Haskell-Luevano C. Doering SR, et al. Among authors: houghten ra. J Med Chem. 2023 May 25;66(10):7063-7065. doi: 10.1021/acs.jmedchem.3c00588. Epub 2023 May 8. J Med Chem. 2023. PMID: 37155917 No abstract available.
Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist.
Ericson MD, Doering SR, Larson CM, Freeman KT, LaVoi TM, Donow HM, Santos RG, Cho RH, Koerperich ZM, Giulianotti MA, Pinilla C, Houghten RA, Haskell-Luevano C. Ericson MD, et al. Among authors: houghten ra. J Med Chem. 2021 Oct 14;64(19):14860-14875. doi: 10.1021/acs.jmedchem.1c01417. Epub 2021 Sep 30. J Med Chem. 2021. PMID: 34592820 Free PMC article.
Novel Cyclic Lipopeptides Fusaricidin Analogs for Treating Wound Infections.
Gil J, Pastar I, Houghten RA, Padhee S, Higa A, Solis M, Valdez J, Head CR, Michaels H, Lenhart B, Simms C, Williams B, Cudic P, Davis SC. Gil J, et al. Among authors: houghten ra. Front Microbiol. 2021 Jul 23;12:708904. doi: 10.3389/fmicb.2021.708904. eCollection 2021. Front Microbiol. 2021. PMID: 34367114 Free PMC article.
Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign.
Doering SR, Freeman K, Debevec G, Geer P, Santos RG, Lavoi TM, Giulianotti MA, Pinilla C, Appel JR, Houghten RA, Ericson MD, Haskell-Luevano C. Doering SR, et al. Among authors: houghten ra. J Med Chem. 2021 May 13;64(9):5577-5592. doi: 10.1021/acs.jmedchem.0c02041. Epub 2021 Apr 22. J Med Chem. 2021. PMID: 33886285 Free PMC article.
The value of antimicrobial peptides in the age of resistance.
Magana M, Pushpanathan M, Santos AL, Leanse L, Fernandez M, Ioannidis A, Giulianotti MA, Apidianakis Y, Bradfute S, Ferguson AL, Cherkasov A, Seleem MN, Pinilla C, de la Fuente-Nunez C, Lazaridis T, Dai T, Houghten RA, Hancock REW, Tegos GP. Magana M, et al. Among authors: houghten ra. Lancet Infect Dis. 2020 Sep;20(9):e216-e230. doi: 10.1016/S1473-3099(20)30327-3. Epub 2020 Jul 9. Lancet Infect Dis. 2020. PMID: 32653070 Review.
411 results