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Lrp5 functions in bone to regulate bone mass.
Cui Y, Niziolek PJ, MacDonald BT, Zylstra CR, Alenina N, Robinson DR, Zhong Z, Matthes S, Jacobsen CM, Conlon RA, Brommage R, Liu Q, Mseeh F, Powell DR, Yang QM, Zambrowicz B, Gerrits H, Gossen JA, He X, Bader M, Williams BO, Warman ML, Robling AG. Cui Y, et al. Among authors: williams bo. Nat Med. 2011 Jun;17(6):684-91. doi: 10.1038/nm.2388. Epub 2011 May 22. Nat Med. 2011. PMID: 21602802 Free PMC article.
Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6.
Holmen SL, Giambernardi TA, Zylstra CR, Buckner-Berghuis BD, Resau JH, Hess JF, Glatt V, Bouxsein ML, Ai M, Warman ML, Williams BO. Holmen SL, et al. Among authors: williams bo. J Bone Miner Res. 2004 Dec;19(12):2033-40. doi: 10.1359/JBMR.040907. Epub 2004 Sep 13. J Bone Miner Res. 2004. PMID: 15537447 Free article.
Essential role of beta-catenin in postnatal bone acquisition.
Holmen SL, Zylstra CR, Mukherjee A, Sigler RE, Faugere MC, Bouxsein ML, Deng L, Clemens TL, Williams BO. Holmen SL, et al. Among authors: williams bo. J Biol Chem. 2005 Jun 3;280(22):21162-8. doi: 10.1074/jbc.M501900200. Epub 2005 Mar 31. J Biol Chem. 2005. PMID: 15802266 Free article.
Lifelong accumulation of bone in mice lacking Pten in osteoblasts.
Liu X, Bruxvoort KJ, Zylstra CR, Liu J, Cichowski R, Faugere MC, Bouxsein ML, Wan C, Williams BO, Clemens TL. Liu X, et al. Among authors: williams bo. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2259-64. doi: 10.1073/pnas.0604153104. Epub 2007 Feb 7. Proc Natl Acad Sci U S A. 2007. PMID: 17287359 Free PMC article.
Inactivation of Apc in the mouse prostate causes prostate carcinoma.
Bruxvoort KJ, Charbonneau HM, Giambernardi TA, Goolsby JC, Qian CN, Zylstra CR, Robinson DR, Roy-Burman P, Shaw AK, Buckner-Berghuis BD, Sigler RE, Resau JH, Sullivan R, Bushman W, Williams BO. Bruxvoort KJ, et al. Among authors: williams bo. Cancer Res. 2007 Mar 15;67(6):2490-6. doi: 10.1158/0008-5472.CAN-06-3028. Cancer Res. 2007. PMID: 17363566
202 results