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MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma.
J Clin Invest. 2024 Apr 15;134(8):e181338. doi: 10.1172/JCI181338.
J Clin Invest. 2024.
PMID: 38618965
Free PMC article.
No abstract available.
Discovery of indazole-pyridinone derivatives as a novel class of potent and selective MNK1/2 kinase inhibitors that protecting against endotoxin-induced septic shock.
Dreas A, Kucwaj-Brysz K, Pyziak K, Kulesza U, Wincza E, Fabritius CH, Michalik K, Gabor-Worwa E, Gołas A, Milik M, Masiejczyk M, Majewska E, Pyśniak K, Wójcik-Trechcińska U, Sandowska-Markiewicz Z, Brzózka K, Ostrowski J, Rzymski T, Mikula M.
Dreas A, et al.
Eur J Med Chem. 2021 Mar 5;213:113057. doi: 10.1016/j.ejmech.2020.113057. Epub 2020 Dec 1.
Eur J Med Chem. 2021.
PMID: 33303237
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How to design potent and selective DYRK1B inhibitors? Molecular modeling study.
Szamborska-Gbur A, Rutkowska E, Dreas A, Frid M, Vilenchik M, Milik M, Brzózka K, Król M.
Szamborska-Gbur A, et al. Among authors: dreas a.
J Mol Model. 2019 Jan 23;25(2):41. doi: 10.1007/s00894-018-3921-3.
J Mol Model. 2019.
PMID: 30673861
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MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma.
Zhan Y, Guo J, Yang W, Goncalves C, Rzymski T, Dreas A, Żyłkiewicz E, Mikulski M, Brzózka K, Golas A, Kong Y, Ma M, Huang F, Huor B, Guo Q, da Silva SD, Torres J, Cai Y, Topisirovic I, Su J, Bijian K, Alaoui-Jamali MA, Huang S, Journe F, Ghanem GE, Miller WH Jr, Del Rincón SV.
Zhan Y, et al. Among authors: dreas a.
J Clin Invest. 2017 Nov 1;127(11):4179-4192. doi: 10.1172/JCI91258. Epub 2017 Oct 16.
J Clin Invest. 2017.
PMID: 29035277
Free PMC article.
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SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains.
Rzymski T, Mikula M, Żyłkiewicz E, Dreas A, Wiklik K, Gołas A, Wójcik K, Masiejczyk M, Wróbel A, Dolata I, Kitlińska A, Statkiewicz M, Kuklinska U, Goryca K, Sapała Ł, Grochowska A, Cabaj A, Szajewska-Skuta M, Gabor-Worwa E, Kucwaj K, Białas A, Radzimierski A, Combik M, Woyciechowski J, Mikulski M, Windak R, Ostrowski J, Brzózka K.
Rzymski T, et al. Among authors: dreas a.
Oncotarget. 2017 May 16;8(20):33779-33795. doi: 10.18632/oncotarget.16810.
Oncotarget. 2017.
PMID: 28422713
Free PMC article.
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Mitogen-activated Protein Kinase (MAPK) Interacting Kinases 1 and 2 (MNK1 and MNK2) as Targets for Cancer Therapy: Recent Progress in the Development of MNK Inhibitors.
Dreas A, Mikulski M, Milik M, Fabritius CH, Brzózka K, Rzymski T.
Dreas A, et al.
Curr Med Chem. 2017;24(28):3025-3053. doi: 10.2174/0929867324666170203123427.
Curr Med Chem. 2017.
PMID: 28164761
Review.
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(4S)-(-)-4-Benzyl-2,2-dimethyl-3-o-toluoyl-1,3-oxazolidine.
Gzella AK, Chrzanowska M, Dreas A, Meissner Z.
Gzella AK, et al. Among authors: dreas a.
Acta Crystallogr Sect E Struct Rep Online. 2010 Oct 20;66(Pt 11):o2850. doi: 10.1107/S1600536810040699.
Acta Crystallogr Sect E Struct Rep Online. 2010.
PMID: 21589035
Free PMC article.
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