Yamakawa N - Search Results

1

Synthesis and biological evaluation of loxoprofen derivatives.

Yamakawa N, Suemasu S, Matoyama M, Tanaka K, Katsu T, Miyata K, Okamoto Y, Otsuka M, Mizushima T. Yamakawa N, et al. Bioorg Med Chem. 2011 Jun 1;19(11):3299-311. doi: 10.1016/j.bmc.2011.04.050. Epub 2011 May 1. Bioorg Med Chem. 2011. PMID: 21570308

2

Low direct cytotoxicity of loxoprofen on gastric mucosal cells.

Yamakawa N, Suemasu S, Kimoto A, Arai Y, Ishihara T, Yokomizo K, Okamoto Y, Otsuka M, Tanaka K, Mizushima T. Yamakawa N, et al. Biol Pharm Bull. 2010;33(3):398-403. doi: 10.1248/bpb.33.398. Biol Pharm Bull. 2010. PMID: 20190399 Free article.

3

Properties and synthesis of 2-{2-fluoro (or bromo)-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: nonsteroidal anti-inflammatory drugs with low membrane permeabilizing and gastric lesion-producing activities.

Yamakawa N, Suemasu S, Matoyama M, Kimoto A, Takeda M, Tanaka K, Ishihara T, Katsu T, Okamoto Y, Otsuka M, Mizushima T. Yamakawa N, et al. J Med Chem. 2010 Nov 11;53(21):7879-82. doi: 10.1021/jm101116s. J Med Chem. 2010. PMID: 20954731

4

Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: nonsteroidal anti-inflammatory drugs with low gastric ulcerogenic activity.

Yamakawa N, Suemasu S, Okamoto Y, Tanaka K, Ishihara T, Asano T, Miyata K, Otsuka M, Mizushima T. Yamakawa N, et al. J Med Chem. 2012 Jun 14;55(11):5143-50. doi: 10.1021/jm300049g. Epub 2012 May 16. J Med Chem. 2012. PMID: 22404396

5

Comparison of pharmacokinetics between loxoprofen and its derivative with lower ulcerogenic activity, fluoro-loxoprofen.

Yamakawa N, Suemasu S, Watanabe H, Tahara K, Tanaka K, Okamoto Y, Ohtsuka M, Maruyama T, Mizushima T. Yamakawa N, et al. Drug Metab Pharmacokinet. 2013;28(2):118-24. doi: 10.2133/dmpk.dmpk-12-rg-050. Epub 2012 Aug 14. Drug Metab Pharmacokinet. 2013. PMID: 22892443 Free article.

6

Identification of a unique nsaid, fluoro-loxoprofen with gastroprotective activity.

Suemasu S, Yamakawa N, Ishihara T, Asano T, Tahara K, Tanaka K, Matsui H, Okamoto Y, Otsuka M, Takeuchi K, Suzuki H, Mizushima T. Suemasu S, et al. Among authors: yamakawa n. Biochem Pharmacol. 2012 Dec 1;84(11):1470-81. doi: 10.1016/j.bcp.2012.09.016. Epub 2012 Sep 26. Biochem Pharmacol. 2012. PMID: 23022227

7

Structure-activity relationship of celecoxib and rofecoxib for the membrane permeabilizing activity.

Yamakawa N, Suzuki K, Yamashita Y, Katsu T, Hanaya K, Shoji M, Sugai T, Mizushima T. Yamakawa N, et al. Bioorg Med Chem. 2014 Apr 15;22(8):2529-34. doi: 10.1016/j.bmc.2014.02.032. Epub 2014 Mar 12. Bioorg Med Chem. 2014. PMID: 24650702

8

Antinociception by fluoro-loxoprofen, a novel non-steroidal anti-inflammatory drug with less ulcerogenic effects, in rat models of inflammatory pain.

Asano T, Hattori T, Tanaka KI, Yamakawa N, Suemasu S, Aida S, Kataoka M, Mizushima T, Takenaga M. Asano T, et al. Among authors: yamakawa n. Eur J Pharmacol. 2019 Feb 5;844:253-258. doi: 10.1016/j.ejphar.2018.12.008. Epub 2018 Dec 6. Eur J Pharmacol. 2019. PMID: 30529473

9

Chemical modification-mediated optimisation of bronchodilatory activity of mepenzolate, a muscarinic receptor antagonist with anti-inflammatory activity.

Yamashita Y, Tanaka KI, Yamakawa N, Asano T, Kanda Y, Takafuji A, Kawahara M, Takenaga M, Fukunishi Y, Mizushima T. Yamashita Y, et al. Among authors: yamakawa n. Bioorg Med Chem. 2019 Aug 1;27(15):3339-3346. doi: 10.1016/j.bmc.2019.06.016. Epub 2019 Jun 8. Bioorg Med Chem. 2019. PMID: 31204225

10

Synthesis of prostaglandin E(1) phosphate derivatives and their encapsulation in biodegradable nanoparticles.

Takeda M, Maeda T, Ishihara T, Sakamoto H, Yuki K, Takasaki N, Nishimura F, Yamashita T, Tanaka K, Takenaga M, Igarashi R, Higaki M, Yamakawa N, Okamoto Y, Ogawa H, Otsuka M, Mizushima Y, Mizushima T. Takeda M, et al. Among authors: yamakawa n. Pharm Res. 2009 Jul;26(7):1792-800. doi: 10.1007/s11095-009-9891-5. Epub 2009 May 5. Pharm Res. 2009. PMID: 19415470

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