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Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents.
Gupta SC, Prasad S, Reuter S, Kannappan R, Yadav VR, Ravindran J, Hema PS, Chaturvedi MM, Nair M, Aggarwal BB. Gupta SC, et al. J Biol Chem. 2010 Nov 12;285(46):35406-17. doi: 10.1074/jbc.M110.161984. Epub 2010 Sep 9. J Biol Chem. 2010. PMID: 20829362 Free PMC article.
Oxidative stress, inflammation, and cancer: how are they linked?
Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. Reuter S, et al. Among authors: gupta sc. Free Radic Biol Med. 2010 Dec 1;49(11):1603-16. doi: 10.1016/j.freeradbiomed.2010.09.006. Epub 2010 Sep 16. Free Radic Biol Med. 2010. PMID: 20840865 Free PMC article. Review.
Bharangin, a diterpenoid quinonemethide, abolishes constitutive and inducible nuclear factor-κB (NF-κB) activation by modifying p65 on cysteine 38 residue and reducing inhibitor of nuclear factor-κB α kinase activation, leading to suppression of NF-κB-regulated gene expression and sensitization of tumor cells to chemotherapeutic agents.
Gupta SC, Kannappan R, Kim J, Rahman GM, Francis SK, Raveendran R, Nair MS, Das J, Aggarwal BB. Gupta SC, et al. Mol Pharmacol. 2011 Nov;80(5):769-81. doi: 10.1124/mol.111.073122. Epub 2011 Jul 27. Mol Pharmacol. 2011. PMID: 21795584 Free PMC article.
Turmeric (Curcuma longa) inhibits inflammatory nuclear factor (NF)-κB and NF-κB-regulated gene products and induces death receptors leading to suppressed proliferation, induced chemosensitization, and suppressed osteoclastogenesis.
Kim JH, Gupta SC, Park B, Yadav VR, Aggarwal BB. Kim JH, et al. Among authors: gupta sc. Mol Nutr Food Res. 2012 Mar;56(3):454-65. doi: 10.1002/mnfr.201100270. Epub 2011 Dec 7. Mol Nutr Food Res. 2012. PMID: 22147524 Free PMC article.
Chemosensitization of tumors by resveratrol.
Gupta SC, Kannappan R, Reuter S, Kim JH, Aggarwal BB. Gupta SC, et al. Ann N Y Acad Sci. 2011 Jan;1215:150-60. doi: 10.1111/j.1749-6632.2010.05852.x. Ann N Y Acad Sci. 2011. PMID: 21261654 Free PMC article. Review.
693 results