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Identification of HEXIM1 as a positive regulator of p53.
Lew QJ, Chia YL, Chu KL, Lam YT, Gurumurthy M, Xu S, Lam KP, Cheong N, Chao SH. Lew QJ, et al. Among authors: gurumurthy m. J Biol Chem. 2012 Oct 19;287(43):36443-54. doi: 10.1074/jbc.M112.374157. Epub 2012 Sep 4. J Biol Chem. 2012. PMID: 22948151 Free PMC article.
HEXIM1 induces differentiation of human pluripotent stem cells.
Ding V, Lew QJ, Chu KL, Natarajan S, Rajasegaran V, Gurumurthy M, Choo AB, Chao SH. Ding V, et al. Among authors: gurumurthy m. PLoS One. 2013 Aug 20;8(8):e72823. doi: 10.1371/journal.pone.0072823. eCollection 2013. PLoS One. 2013. PMID: 23977357 Free PMC article.
Substrate specificity of the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic nitroimidazoles.
Gurumurthy M, Mukherjee T, Dowd CS, Singh R, Niyomrattanakit P, Tay JA, Nayyar A, Lee YS, Cherian J, Boshoff HI, Dick T, Barry CE 3rd, Manjunatha UH. Gurumurthy M, et al. FEBS J. 2012 Jan;279(1):113-25. doi: 10.1111/j.1742-4658.2011.08404.x. Epub 2011 Nov 14. FEBS J. 2012. PMID: 22023140 Free PMC article.
Structure of Ddn, the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824.
Cellitti SE, Shaffer J, Jones DH, Mukherjee T, Gurumurthy M, Bursulaya B, Boshoff HI, Choi I, Nayyar A, Lee YS, Cherian J, Niyomrattanakit P, Dick T, Manjunatha UH, Barry CE 3rd, Spraggon G, Geierstanger BH. Cellitti SE, et al. Among authors: gurumurthy m. Structure. 2012 Jan 11;20(1):101-12. doi: 10.1016/j.str.2011.11.001. Structure. 2012. PMID: 22244759 Free PMC article.
Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824.
Cellitti SE, Shaffer J, Jones DH, Mukherjee T, Gurumurthy M, Bursulaya B, Boshoff HI, Choi I, Nayyar A, Lee YS, Cherian J, Niyomrattanakit P, Dick T, Manjunatha UH, Barry CE 3rd, Spraggon G, Geierstanger BH. Cellitti SE, et al. Among authors: gurumurthy m. Structure. 2013 Jan 8;21(1):191. doi: 10.1016/j.str.2012.12.012. Epub 2013 Jan 8. Structure. 2013. PMID: 28903033 Free PMC article. No abstract available.
Pharmacokinetics-pharmacodynamics analysis of bicyclic 4-nitroimidazole analogs in a murine model of tuberculosis.
Lakshminarayana SB, Boshoff HI, Cherian J, Ravindran S, Goh A, Jiricek J, Nanjundappa M, Nayyar A, Gurumurthy M, Singh R, Dick T, Blasco F, Barry CE 3rd, Ho PC, Manjunatha UH. Lakshminarayana SB, et al. Among authors: gurumurthy m. PLoS One. 2014 Aug 20;9(8):e105222. doi: 10.1371/journal.pone.0105222. eCollection 2014. PLoS One. 2014. PMID: 25141257 Free PMC article.
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