The conserved protein EF4 (LepA) modulates the elongation cycle of protein synthesis.
Liu H, Chen C, Zhang H, Kaur J, Goldman YE, Cooperman BS.
Liu H, et al.
Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16223-8. doi: 10.1073/pnas.1103820108. Epub 2011 Sep 19.
Proc Natl Acad Sci U S A. 2011.
PMID: 21930951
Free PMC article.
Such EF4 binding results in formation of a complex, denoted X(3), that effectively sequesters a catalytically active ribosome, leading to a transient inhibition of elongation that provides a mechanism for optimization of functional protein synthesis. Earlier [Liu H, …
Such EF4 binding results in formation of a complex, denoted X(3), that effectively sequesters a catalytically active ribosome, leading to a …