Kim DH - Search Results

1

Effects of the anti-sepsis drug, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD-712), on mortality, inflammation, and organ injuries in rodent sepsis models.

Park JH, Hwang IC, Ha N, Lee S, Kim JM, Lee SS, Yu H, Lim IT, You JA, Kim DH. Park JH, et al. Among authors: kim jm, kim dh. Arch Pharm Res. 2011 Mar;34(3):485-94. doi: 10.1007/s12272-011-0318-6. Epub 2011 May 6. Arch Pharm Res. 2011. PMID: 21547682

2

Carcinogenicity study of CKD-501, a novel dual peroxisome proliferator-activated receptors α and γ agonist, following oral administration to Sprague Dawley rats for 94-101 weeks.

Lee HS, Chang M, Lee JE, Kim W, Hwang IC, Kim DH, Park HK, Choi HJ, Jo W, Cha SW, Son WC. Lee HS, et al. Among authors: kim w, kim dh. Regul Toxicol Pharmacol. 2014 Jul;69(2):207-16. doi: 10.1016/j.yrtph.2014.04.003. Epub 2014 Apr 18. Regul Toxicol Pharmacol. 2014. PMID: 24747398

3

CKD-501, a novel selective PPARγ agonist, shows no carcinogenic potential in ICR mice following oral administration for 104 weeks.

Moon KS, Lee JE, Lee HS, Hwang IC, Kim DH, Park HK, Choi HJ, Jo W, Son WC, Yun HI. Moon KS, et al. Among authors: kim dh. J Appl Toxicol. 2014 Dec;34(12):1271-84. doi: 10.1002/jat.2918. Epub 2013 Sep 12. J Appl Toxicol. 2014. PMID: 24026970

4

HO-1 and JAK-2/STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline alkaloid, CKD712, in cells activated with lipopolysacchride.

Tsoyi K, Kim HJ, Shin JS, Kim DH, Cho HJ, Lee SS, Ahn SK, Yun-Choi HS, Lee JH, Seo HG, Chang KC. Tsoyi K, et al. Among authors: kim hj, kim dh. Cell Signal. 2008 Oct;20(10):1839-47. doi: 10.1016/j.cellsig.2008.06.012. Epub 2008 Jun 27. Cell Signal. 2008. PMID: 18634870

5

CKD712, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, inhibits the lipopolysaccharide-stimulated secretion of HMGB1 by inhibiting PI3K and classical protein kinase C.

Oh YJ, Youn JH, Min HJ, Kim DH, Lee SS, Choi IH, Shin JS. Oh YJ, et al. Among authors: kim dh. Int Immunopharmacol. 2011 Sep;11(9):1160-5. doi: 10.1016/j.intimp.2011.03.013. Epub 2011 Mar 30. Int Immunopharmacol. 2011. PMID: 21457762

6

Discovery of a potent tubulin polymerization inhibitor: synthesis and evaluation of water-soluble prodrugs of benzophenone analog.

Lee J, Bae S, Lee SH, Choi H, Kim YH, Kim SJ, Park GT, Moon SK, Kim DH, Lee S, Ahn SK, Choi NS, Lee KJ. Lee J, et al. Among authors: kim yh, kim dh, kim sj. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6327-30. doi: 10.1016/j.bmcl.2010.05.060. Epub 2010 May 20. Bioorg Med Chem Lett. 2010. PMID: 20850313

7

Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors.

Lee J, Kim SJ, Choi H, Kim YH, Lim IT, Yang HM, Lee CS, Kang HR, Ahn SK, Moon SK, Kim DH, Lee S, Choi NS, Lee KJ. Lee J, et al. Among authors: kim yh, kim dh, kim sj. J Med Chem. 2010 Sep 9;53(17):6337-54. doi: 10.1021/jm1002414. J Med Chem. 2010. PMID: 20690624

8

CKD-712, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Inhibits the NF-κB Activation and Augments Akt Activation during TLR4 Signaling.

Lee J, Yang EJ, Shin JS, Kim DH, Lee SS, Choi IH. Lee J, et al. Among authors: kim dh. Immune Netw. 2011 Dec;11(6):420-3. doi: 10.4110/in.2011.11.6.420. Epub 2011 Dec 31. Immune Netw. 2011. PMID: 22346785 Free PMC article.

9

(S)-tetrahydroisoquinoline alkaloid inhibits LPS-induced arachidonic acid release through downregulation of cPLA2 expression.

Choi JM, Choi YH, Kim SK, Ahn KH, Won JH, Lim JH, Jang YJ, Lee S, Kim DH, Kim DK. Choi JM, et al. Among authors: kim dh, kim dk, kim sk. Mol Cells. 2013 Nov;36(5):400-9. doi: 10.1007/s10059-013-0078-x. Epub 2013 Nov 14. Mol Cells. 2013. PMID: 24293010 Free PMC article.

10

Enhanced efficacy of CKD-516 in combination with doxorubicin: pre-clinical evaluation using a hepatocellular carcinoma xenograft model.

Kim YI, Kim KW, Lee HK, Park J, Chung JW, Youn H, Kim SJ, Kim DH, Tseng JC, Lee JM. Kim YI, et al. Among authors: kim dh, kim sj, kim kw. Anticancer Res. 2014 Apr;34(4):1715-22. Anticancer Res. 2014. PMID: 24692701

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