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3-Trifluoromethylquinoxaline N,N'-dioxides as anti-trypanosomatid agents. Identification of optimal anti-T. cruzi agents and mechanism of action studies.
Benitez D, Cabrera M, Hernández P, Boiani L, Lavaggi ML, Di Maio R, Yaluff G, Serna E, Torres S, Ferreira ME, Vera de Bilbao N, Torres E, Pérez-Silanes S, Solano B, Moreno E, Aldana I, López de Ceráin A, Cerecetto H, González M, Monge A. Benitez D, et al. Among authors: serna e. J Med Chem. 2011 May 26;54(10):3624-36. doi: 10.1021/jm2002469. Epub 2011 May 4. J Med Chem. 2011. PMID: 21506600
In vitro and in vivo antitrypanosomatid activity of 5-nitroindazoles.
Boiani L, Gerpe A, Arán VJ, Torres de Ortiz S, Serna E, Vera de Bilbao N, Sanabria L, Yaluff G, Nakayama H, Rojas de Arias A, Maya JD, Morello JA, Cerecetto H, González M. Boiani L, et al. Among authors: serna e. Eur J Med Chem. 2009 Mar;44(3):1034-40. doi: 10.1016/j.ejmech.2008.06.024. Epub 2008 Jun 28. Eur J Med Chem. 2009. PMID: 18706738
Zanthoxylum chiloperone leaves extract: first sustainable Chagas disease treatment.
Ferreira ME, Cebrián-Torrejón G, Corrales AS, Vera de Bilbao N, Rolón M, Gomez CV, Leblanc K, Yaluf G, Schinini A, Torres S, Serna E, Rojas de Arias A, Poupon E, Fournet A. Ferreira ME, et al. Among authors: serna e. J Ethnopharmacol. 2011 Feb 16;133(3):986-93. doi: 10.1016/j.jep.2010.11.032. Epub 2010 Dec 4. J Ethnopharmacol. 2011. PMID: 21134431
Optimization of antitrypanosomatid agents: identification of nonmutagenic drug candidates with in vivo activity.
Álvarez G, Varela J, Márquez P, Gabay M, Arias Rivas CE, Cuchilla K, Echeverría GA, Piro OE, Chorilli M, Leal SM, Escobar P, Serna E, Torres S, Yaluff G, Vera de Bilbao NI, González M, Cerecetto H. Álvarez G, et al. Among authors: serna e. J Med Chem. 2014 May 22;57(10):3984-99. doi: 10.1021/jm500018m. Epub 2014 May 2. J Med Chem. 2014. PMID: 24749923
Identification of a new amide-containing thiazole as a drug candidate for treatment of Chagas' disease.
Álvarez G, Varela J, Cruces E, Fernández M, Gabay M, Leal SM, Escobar P, Sanabria L, Serna E, Torres S, Figueredo Thiel SJ, Yaluff G, Vera de Bilbao NI, Cerecetto H, González M. Álvarez G, et al. Among authors: serna e. Antimicrob Agents Chemother. 2015 Mar;59(3):1398-404. doi: 10.1128/AAC.03814-14. Epub 2014 Dec 15. Antimicrob Agents Chemother. 2015. PMID: 25512408 Free PMC article.
Development of bis-thiazoles as inhibitors of triosephosphate isomerase from Trypanosoma cruzi. Identification of new non-mutagenic agents that are active in vivo.
Álvarez G, Martínez J, Varela J, Birriel E, Cruces E, Gabay M, Leal SM, Escobar P, Aguirre-López B, Cabrera N, Tuena de Gómez-Puyou M, Gómez Puyou A, Pérez-Montfort R, Yaluff G, Torres S, Serna E, Vera de Bilbao N, González M, Cerecetto H. Álvarez G, et al. Among authors: serna e. Eur J Med Chem. 2015 Jul 15;100:246-56. doi: 10.1016/j.ejmech.2015.06.018. Epub 2015 Jun 12. Eur J Med Chem. 2015. PMID: 26094151
Potent and Selective Inhibitors of Trypanosoma cruzi Triosephosphate Isomerase with Concomitant Inhibition of Cruzipain: Inhibition of Parasite Growth through Multitarget Activity.
Aguilera E, Varela J, Birriel E, Serna E, Torres S, Yaluff G, de Bilbao NV, Aguirre-López B, Cabrera N, Díaz Mazariegos S, de Gómez-Puyou MT, Gómez-Puyou A, Pérez-Montfort R, Minini L, Merlino A, Cerecetto H, González M, Alvarez G. Aguilera E, et al. Among authors: serna e. ChemMedChem. 2016 Jun 20;11(12):1328-38. doi: 10.1002/cmdc.201500385. Epub 2015 Oct 23. ChemMedChem. 2016. PMID: 26492824
207 results