Pais GC - Search Results

1

Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).

Kim HY, Wiles JA, Wang Q, Pais GC, Lucien E, Hashimoto A, Nelson DM, Thanassi JA, Podos SD, Deshpande M, Pucci MJ, Bradbury BJ. Kim HY, et al. Among authors: pais gc. J Med Chem. 2011 May 12;54(9):3268-82. doi: 10.1021/jm101604v. Epub 2011 Apr 15. J Med Chem. 2011. PMID: 21425851

2

Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions.

Wang Q, Lucien E, Hashimoto A, Pais GC, Nelson DM, Song Y, Thanassi JA, Marlor CW, Thoma CL, Cheng J, Podos SD, Ou Y, Deshpande M, Pucci MJ, Buechter DD, Bradbury BJ, Wiles JA. Wang Q, et al. Among authors: pais gc. J Med Chem. 2007 Jan 25;50(2):199-210. doi: 10.1021/jm060844e. J Med Chem. 2007. PMID: 17228862

3

Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors.

Pais GC, Zhang X, Marchand C, Neamati N, Cowansage K, Svarovskaia ES, Pathak VK, Tang Y, Nicklaus M, Pommier Y, Burke TR Jr. Pais GC, et al. J Med Chem. 2002 Jul 18;45(15):3184-94. doi: 10.1021/jm020037p. J Med Chem. 2002. PMID: 12109903

4

Metal-dependent inhibition of HIV-1 integrase.

Neamati N, Lin Z, Karki RG, Orr A, Cowansage K, Strumberg D, Pais GC, Voigt JH, Nicklaus MC, Winslow HE, Zhao H, Turpin JA, Yi J, Skalka AM, Burke TR Jr, Pommier Y. Neamati N, et al. Among authors: pais gc. J Med Chem. 2002 Dec 19;45(26):5661-70. doi: 10.1021/jm0201417. J Med Chem. 2002. PMID: 12477350

5

Utilization of a peptide lead for the discovery of a novel PTP1B-binding motif.

Gao Y, Voigt J, Zhao H, Pais GC, Zhang X, Wu L, Zhang ZY, Burke TR Jr. Gao Y, et al. Among authors: pais gc. J Med Chem. 2001 Aug 30;44(18):2869-78. doi: 10.1021/jm010020r. J Med Chem. 2001. PMID: 11520195

6

Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors.

Zhang X, Pais GC, Svarovskaia ES, Marchand C, Johnson AA, Karki RG, Nicklaus MC, Pathak VK, Pommier Y, Burke TR. Zhang X, et al. Among authors: pais gc. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1215-9. doi: 10.1016/s0960-894x(03)00059-3. Bioorg Med Chem Lett. 2003. PMID: 12643946

7

Structural determinants for HIV-1 integrase inhibition by beta-diketo acids.

Marchand C, Zhang X, Pais GC, Cowansage K, Neamati N, Burke TR Jr, Pommier Y. Marchand C, et al. Among authors: pais gc. J Biol Chem. 2002 Apr 12;277(15):12596-603. doi: 10.1074/jbc.M110758200. Epub 2002 Jan 22. J Biol Chem. 2002. PMID: 11805103 Free article.

8

Metal-dependent inhibition of HIV-1 integrase by beta-diketo acids and resistance of the soluble double-mutant (F185K/C280S).

Marchand C, Johnson AA, Karki RG, Pais GC, Zhang X, Cowansage K, Patel TA, Nicklaus MC, Burke TR Jr, Pommier Y. Marchand C, et al. Among authors: pais gc. Mol Pharmacol. 2003 Sep;64(3):600-9. doi: 10.1124/mol.64.3.600. Mol Pharmacol. 2003. PMID: 12920196

9

Azido-containing diketo acid derivatives inhibit human immunodeficiency virus type 1 integrase in vivo and influence the frequency of deletions at two-long-terminal-repeat-circle junctions.

Svarovskaia ES, Barr R, Zhang X, Pais GC, Marchand C, Pommier Y, Burke TR Jr, Pathak VK. Svarovskaia ES, et al. Among authors: pais gc. J Virol. 2004 Apr;78(7):3210-22. doi: 10.1128/jvi.78.7.3210-3222.2004. J Virol. 2004. PMID: 15016842 Free PMC article.

10

Integration requires a specific interaction of the donor DNA terminal 5'-cytosine with glutamine 148 of the HIV-1 integrase flexible loop.

Johnson AA, Santos W, Pais GC, Marchand C, Amin R, Burke TR Jr, Verdine G, Pommier Y. Johnson AA, et al. Among authors: pais gc. J Biol Chem. 2006 Jan 6;281(1):461-7. doi: 10.1074/jbc.M511348200. Epub 2005 Oct 27. J Biol Chem. 2006. PMID: 16257967 Free article.

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