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Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).
J Med Chem. 2011 May 12;54(9):3268-82. doi: 10.1021/jm101604v. Epub 2011 Apr 15.
J Med Chem. 2011.
PMID: 21425851
Biological evaluation of isothiazoloquinolones containing aromatic heterocycles at the 7-position: In vitro activity of a series of potent antibacterial agents that are effective against methicillin-resistant Staphylococcus aureus.
Wiles JA, Song Y, Wang Q, Lucien E, Hashimoto A, Cheng J, Marlor CW, Ou Y, Podos SD, Thanassi JA, Thoma CL, Deshpande M, Pucci MJ, Bradbury BJ.
Wiles JA, et al. Among authors: lucien e.
Bioorg Med Chem Lett. 2006 Mar 1;16(5):1277-81. doi: 10.1016/j.bmcl.2005.11.064. Epub 2005 Dec 7.
Bioorg Med Chem Lett. 2006.
PMID: 16337789
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Isothiazoloquinolones containing functionalized aromatic hydrocarbons at the 7-position: synthesis and in vitro activity of a series of potent antibacterial agents with diminished cytotoxicity in human cells.
Wiles JA, Wang Q, Lucien E, Hashimoto A, Song Y, Cheng J, Marlor CW, Ou Y, Podos SD, Thanassi JA, Thoma CL, Deshpande M, Pucci MJ, Bradbury BJ.
Wiles JA, et al. Among authors: lucien e.
Bioorg Med Chem Lett. 2006 Mar 1;16(5):1272-6. doi: 10.1016/j.bmcl.2005.11.065. Epub 2005 Dec 7.
Bioorg Med Chem Lett. 2006.
PMID: 16337791
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Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions.
Wang Q, Lucien E, Hashimoto A, Pais GC, Nelson DM, Song Y, Thanassi JA, Marlor CW, Thoma CL, Cheng J, Podos SD, Ou Y, Deshpande M, Pucci MJ, Buechter DD, Bradbury BJ, Wiles JA.
Wang Q, et al. Among authors: lucien e.
J Med Chem. 2007 Jan 25;50(2):199-210. doi: 10.1021/jm060844e.
J Med Chem. 2007.
PMID: 17228862
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Electrophilic oxidant produced in the photodeoxygenation of 1,2-benzodiphenylene sulfoxide.
Lucien E, Greer A.
Lucien E, et al.
J Org Chem. 2001 Jun 29;66(13):4576-9. doi: 10.1021/jo010009z.
J Org Chem. 2001.
PMID: 11421776
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