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Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.
Randall KL, Lambe T, Johnson AL, Treanor B, Kucharska E, Domaschenz H, Whittle B, Tze LE, Enders A, Crockford TL, Bouriez-Jones T, Alston D, Cyster JG, Lenardo MJ, Mackay F, Deenick EK, Tangye SG, Chan TD, Camidge T, Brink R, Vinuesa CG, Batista FD, Cornall RJ, Goodnow CC. Randall KL, et al. Among authors: tze le. Nat Immunol. 2009 Dec;10(12):1283-91. doi: 10.1038/ni.1820. Epub 2009 Nov 8. Nat Immunol. 2009. PMID: 19898472 Free PMC article.
CD5 maintains tolerance in anergic B cells.
Hippen KL, Tze LE, Behrens TW. Hippen KL, et al. Among authors: tze le. J Exp Med. 2000 Mar 6;191(5):883-90. doi: 10.1084/jem.191.5.883. J Exp Med. 2000. PMID: 10704468 Free PMC article.
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