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Metabolism of ophthalmic timolol: new aspects of an old drug.
Basic Clin Pharmacol Toxicol. 2011 May;108(5):297-303. doi: 10.1111/j.1742-7843.2011.00694.x.
Basic Clin Pharmacol Toxicol. 2011.
PMID: 21385322
Free article.
Review.
Timolol metabolism in human liver microsomes is mediated principally by CYP2D6.
Volotinen M, Turpeinen M, Tolonen A, Uusitalo J, Mäenpää J, Pelkonen O.
Volotinen M, et al.
Drug Metab Dispos. 2007 Jul;35(7):1135-41. doi: 10.1124/dmd.106.012906. Epub 2007 Apr 12.
Drug Metab Dispos. 2007.
PMID: 17431033
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Ophthalmic timolol in a hydrogel vehicle leads to minor inter-individual variation in timolol concentration in aqueous humor.
Volotinen M, Mäenpää J, Kautiainen H, Tolonen A, Uusitalo J, Ropo A, Vapaatalo H, Aine E.
Volotinen M, et al.
Eur J Pharm Sci. 2009 Feb 15;36(2-3):292-6. doi: 10.1016/j.ejps.2008.10.004. Epub 2008 Nov 1.
Eur J Pharm Sci. 2009.
PMID: 19013521
Clinical Trial.
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Effects of selective serotonin reuptake inhibitors on timolol metabolism in human liver microsomes and cryo-preserved hepatocytes.
Volotinen M, Korjamo T, Tolonen A, Turpeinen M, Pelkonen O, Hakkola J, Mäenpää J.
Volotinen M, et al.
Basic Clin Pharmacol Toxicol. 2010 Apr;106(4):302-9. doi: 10.1111/j.1742-7843.2009.00487.x. Epub 2009 Nov 11.
Basic Clin Pharmacol Toxicol. 2010.
PMID: 19912165
Free article.
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Expression of cytochrome P450 (CYP) enzymes in human nonpigmented ciliary epithelial cells: induction of CYP1B1 expression by TCDD.
Volotinen M, Mäenpää J, Kankuri E, Oksala O, Pelkonen O, Nakajima M, Yokoi T, Hakkola J.
Volotinen M, et al.
Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3099-105. doi: 10.1167/iovs.08-2790. Epub 2009 Mar 25.
Invest Ophthalmol Vis Sci. 2009.
PMID: 19324859
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