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Synthesis of new glycyrrhetinic acid derived ring A azepanone, 29-urea and 29-hydroxamic acid derivatives as selective 11β-hydroxysteroid dehydrogenase 2 inhibitors.
Gaware R, Khunt R, Czollner L, Stanetty C, Da Cunha T, Kratschmar DV, Odermatt A, Kosma P, Jordis U, Classen-Houben D. Gaware R, et al. Among authors: kratschmar dv. Bioorg Med Chem. 2011 Mar 15;19(6):1866-80. doi: 10.1016/j.bmc.2011.02.005. Epub 2011 Mar 2. Bioorg Med Chem. 2011. PMID: 21376605
11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches.
Rollinger JM, Kratschmar DV, Schuster D, Pfisterer PH, Gumy C, Aubry EM, Brandstötter S, Stuppner H, Wolber G, Odermatt A. Rollinger JM, et al. Among authors: kratschmar dv. Bioorg Med Chem. 2010 Feb 15;18(4):1507-15. doi: 10.1016/j.bmc.2010.01.010. Epub 2010 Jan 11. Bioorg Med Chem. 2010. PMID: 20100662
Novel 11β-hydroxysteroid dehydrogenase 1 inhibitors reduce cortisol levels in keratinocytes and improve dermal collagen content in human ex vivo skin after exposure to cortisone and UV.
Boudon SM, Vuorinen A, Geotti-Bianchini P, Wandeler E, Kratschmar DV, Heidl M, Campiche R, Jackson E, Odermatt A. Boudon SM, et al. Among authors: kratschmar dv. PLoS One. 2017 Feb 2;12(2):e0171079. doi: 10.1371/journal.pone.0171079. eCollection 2017. PLoS One. 2017. PMID: 28152550 Free PMC article.
Identification of the fungicide epoxiconazole by virtual screening and biological assessment as inhibitor of human 11β-hydroxylase and aldosterone synthase.
Akram M, Patt M, Kaserer T, Temml V, Waratchareeyakul W, Kratschmar DV, Haupenthal J, Hartmann RW, Odermatt A, Schuster D. Akram M, et al. Among authors: kratschmar dv. J Steroid Biochem Mol Biol. 2019 Sep;192:105358. doi: 10.1016/j.jsbmb.2019.04.007. Epub 2019 Apr 6. J Steroid Biochem Mol Biol. 2019. PMID: 30965118
39 results