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Page 1
Chiral kinase inhibitors.
Jiang JK, Shen M, Thomas CJ, Boxer MB. Jiang JK, et al. Among authors: boxer mb. Curr Top Med Chem. 2011;11(7):800-9. doi: 10.2174/156802611795165052. Curr Top Med Chem. 2011. PMID: 21291394 Free PMC article. Review.
Elucidation of the structural basis of interaction of the BCR-ABL kinase inhibitor, nilotinib (Tasigna) with the human ABC drug transporter P-glycoprotein.
Shukla S, Chufan EE, Singh S, Skoumbourdis AP, Kapoor K, Boxer MB, Duveau DY, Thomas CJ, Talele TT, Ambudkar SV. Shukla S, et al. Among authors: boxer mb. Leukemia. 2014 Apr;28(4):961-4. doi: 10.1038/leu.2014.21. Epub 2014 Jan 14. Leukemia. 2014. PMID: 24418991 Free PMC article. No abstract available.
A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion.
Kofuji S, Wolfe K, Sumita K, Kageyama S, Yoshino H, Hirota Y, Ogawa-Iio A, Kanoh H, Sasaki M, Kofuji K, Davis MI, Pragani R, Shen M, Boxer MB, Nakatsu F, Nigorikawa K, Sasaki T, Takeuchi K, Senda T, Kim SM, Edinger AL, Simeonov A, Sasaki AT. Kofuji S, et al. Among authors: boxer mb. Biochem Biophys Res Commun. 2024 Jul 23;718:149981. doi: 10.1016/j.bbrc.2024.149981. Epub 2024 Apr 27. Biochem Biophys Res Commun. 2024. PMID: 38735134
Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells.
Ikeda Y, Davis MI, Sumita K, Zheng Y, Kofuji S, Sasaki M, Hirota Y, Pragani R, Shen M, Boxer MB, Takeuchi K, Senda T, Simeonov A, Sasaki AT. Ikeda Y, et al. Among authors: boxer mb. Biochem Biophys Res Commun. 2023 Oct 30;679:116-121. doi: 10.1016/j.bbrc.2023.08.050. Epub 2023 Aug 26. Biochem Biophys Res Commun. 2023. PMID: 37683456 Free article.
SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers.
Shi L, Shen W, Davis MI, Kong K, Vu P, Saha SK, Adil R, Kreuzer J, Egan R, Lee TD, Greninger P, Shrimp JH, Zhao W, Wei TY, Zhou M, Eccleston J, Sussman J, Manocha U, Weerasekara V, Kondo H, Vijay V, Wu MJ, Kearney SE, Ho J, McClanaghan J, Murchie E, Crowther GS, Patnaik S, Boxer MB, Shen M, Ting DT, Kim WY, Stanger BZ, Deshpande V, Ferrone CR, Benes CH, Haas W, Hall MD, Bardeesy N. Shi L, et al. Among authors: boxer mb. Nat Cancer. 2023 Mar;4(3):365-381. doi: 10.1038/s43018-023-00523-0. Epub 2023 Mar 13. Nat Cancer. 2023. PMID: 36914816 Free PMC article.
The HIV protease inhibitor, ritonavir, corrects diverse brain phenotypes across development in mouse model of DYT-TOR1A dystonia.
Caffall ZF, Wilkes BJ, Hernández-Martinez R, Rittiner JE, Fox JT, Wan KK, Shipman MK, Titus SA, Zhang YQ, Patnaik S, Hall MD, Boxer MB, Shen M, Li Z, Vaillancourt DE, Calakos N. Caffall ZF, et al. Among authors: boxer mb. Sci Transl Med. 2021 Aug 18;13(607):eabd3904. doi: 10.1126/scitranslmed.abd3904. Sci Transl Med. 2021. PMID: 34408078 Free PMC article.
Discovery and Optimization of 2H-1λ2-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer.
Rohde JM, Karavadhi S, Pragani R, Liu L, Fang Y, Zhang W, McIver A, Zheng H, Liu Q, Davis MI, Urban DJ, Lee TD, Cheff DM, Hollingshead M, Henderson MJ, Martinez NJ, Brimacombe KR, Yasgar A, Zhao W, Klumpp-Thomas C, Michael S, Covey J, Moore WJ, Stott GM, Li Z, Simeonov A, Jadhav A, Frye S, Hall MD, Shen M, Wang X, Patnaik S, Boxer MB. Rohde JM, et al. Among authors: boxer mb. J Med Chem. 2021 Apr 22;64(8):4913-4946. doi: 10.1021/acs.jmedchem.1c00019. Epub 2021 Apr 6. J Med Chem. 2021. PMID: 33822623 Free PMC article.
Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors.
Manz TD, Sivakumaren SC, Yasgar A, Hall MD, Davis MI, Seo HS, Card JD, Ficarro SB, Shim H, Marto JA, Dhe-Paganon S, Sasaki AT, Boxer MB, Simeonov A, Cantley LC, Shen M, Zhang T, Ferguson FM, Gray NS. Manz TD, et al. Among authors: boxer mb. ACS Med Chem Lett. 2019 Nov 3;11(3):346-352. doi: 10.1021/acsmedchemlett.9b00402. eCollection 2020 Mar 12. ACS Med Chem Lett. 2019. PMID: 32184968 Free PMC article.
73 results