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Evidence for the presence of a critical disulfide bond in the mouse EP3γ receptor.
Prostaglandins Other Lipid Mediat. 2011 Feb;94(1-2):53-8. doi: 10.1016/j.prostaglandins.2010.12.007. Epub 2011 Jan 12.
Prostaglandins Other Lipid Mediat. 2011.
PMID: 21236356
Free PMC article.
Development of an in vivo active, dual EP1 and EP3 selective antagonist based on a novel acyl sulfonamide bioisostere.
Downey JD, Saleh SA, Bridges TM, Morrison RD, Daniels JS, Lindsley CW, Breyer RM.
Downey JD, et al.
Bioorg Med Chem Lett. 2013 Jan 1;23(1):37-41. doi: 10.1016/j.bmcl.2012.11.046. Epub 2012 Nov 24.
Bioorg Med Chem Lett. 2013.
PMID: 23218714
Free PMC article.
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The effect of the EP3 antagonist DG-041 on male mice with diet-induced obesity.
Ceddia RP, Downey JD, Morrison RD, Kraemer MP, Davis SE, Wu J, Lindsley CW, Yin H, Daniels JS, Breyer RM.
Ceddia RP, et al. Among authors: downey jd.
Prostaglandins Other Lipid Mediat. 2019 Oct;144:106353. doi: 10.1016/j.prostaglandins.2019.106353. Epub 2019 Jul 2.
Prostaglandins Other Lipid Mediat. 2019.
PMID: 31276827
Free PMC article.
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PGE2 decreases reactivity of human platelets by activating EP2 and EP4.
Smith JP, Haddad EV, Downey JD, Breyer RM, Boutaud O.
Smith JP, et al. Among authors: downey jd.
Thromb Res. 2010 Jul;126(1):e23-9. doi: 10.1016/j.thromres.2010.04.003. Epub 2010 May 8.
Thromb Res. 2010.
PMID: 20451959
Free PMC article.
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DMTS is an effective treatment in both inhalation and injection models for cyanide poisoning using unanesthetized mice.
DeLeon SM, Downey JD, Hildenberger DM, Rhoomes MO, Booker L, Rockwood GA, Basi KA.
DeLeon SM, et al. Among authors: downey jd.
Clin Toxicol (Phila). 2018 May;56(5):332-341. doi: 10.1080/15563650.2017.1376749. Epub 2017 Sep 19.
Clin Toxicol (Phila). 2018.
PMID: 28922956
Free PMC article.
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