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Critical scaffolding regions of the tumor suppressor Axin1 are natively unfolded.
Noutsou M, Duarte AM, Anvarian Z, Didenko T, Minde DP, Kuper I, de Ridder I, Oikonomou C, Friedler A, Boelens R, Rüdiger SG, Maurice MM. Noutsou M, et al. Among authors: rudiger sg. J Mol Biol. 2011 Jan 21;405(3):773-86. doi: 10.1016/j.jmb.2010.11.013. Epub 2010 Nov 16. J Mol Biol. 2011. PMID: 21087614 Free article.
Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network.
Anvarian Z, Nojima H, van Kappel EC, Madl T, Spit M, Viertler M, Jordens I, Low TY, van Scherpenzeel RC, Kuper I, Richter K, Heck AJ, Boelens R, Vincent JP, Rüdiger SG, Maurice MM. Anvarian Z, et al. Among authors: rudiger sg. Nat Struct Mol Biol. 2016 Apr;23(4):324-32. doi: 10.1038/nsmb.3191. Epub 2016 Mar 14. Nat Struct Mol Biol. 2016. PMID: 26974125
Hsp90 structure and function studied by NMR spectroscopy.
Didenko T, Duarte AM, Karagöz GE, Rüdiger SG. Didenko T, et al. Among authors: rudiger sg. Biochim Biophys Acta. 2012 Mar;1823(3):636-47. doi: 10.1016/j.bbamcr.2011.11.009. Epub 2011 Dec 6. Biochim Biophys Acta. 2012. PMID: 22155720 Free article. Review.
Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled.
Tauriello DV, Jordens I, Kirchner K, Slootstra JW, Kruitwagen T, Bouwman BA, Noutsou M, Rüdiger SG, Schwamborn K, Schambony A, Maurice MM. Tauriello DV, et al. Among authors: rudiger sg. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):E812-20. doi: 10.1073/pnas.1114802109. Epub 2012 Mar 12. Proc Natl Acad Sci U S A. 2012. PMID: 22411803 Free PMC article.
N-terminal domain of human Hsp90 triggers binding to the cochaperone p23.
Karagöz GE, Duarte AM, Ippel H, Uetrecht C, Sinnige T, van Rosmalen M, Hausmann J, Heck AJ, Boelens R, Rüdiger SG. Karagöz GE, et al. Among authors: rudiger sg. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):580-5. doi: 10.1073/pnas.1011867108. Epub 2010 Dec 23. Proc Natl Acad Sci U S A. 2011. PMID: 21183720 Free PMC article.
72 results