Ferris R - Search Results

1

Discovery of N-benzyl-N'-(4-pipyridinyl)urea CCR5 antagonists as anti-HIV-1 agents (I): optimization of the amine portion.

Duan M, Peckham J, Edelstein M, Ferris R, Kazmierski WM, Spaltenstein A, Wheelan P, Xiong Z. Duan M, et al. Among authors: ferris r. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7397-400. doi: 10.1016/j.bmcl.2010.10.033. Epub 2010 Oct 12. Bioorg Med Chem Lett. 2010. PMID: 21035337

2

Discovery of novel pyridyl carboxamides as potent CCR5 antagonists and optimization of their pharmacokinetic profile in rats.

Duan M, Kazmierski WM, Chong PY, Deanda F, Edelstein M, Ferris R, Peckham J, Wheelan P, Xiong Z, Zhang H, Nishizawa R, Takaoka Y. Duan M, et al. Among authors: ferris r. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6470-5. doi: 10.1016/j.bmcl.2011.08.080. Epub 2011 Aug 23. Bioorg Med Chem Lett. 2011. PMID: 21920742

3

Discovery of a novel series of cyclic urea as potent CCR5 antagonists.

Duan M, Kazmierski WM, Tallant M, Jun JH, Edelstein M, Ferris R, Todd D, Wheelan P, Xiong Z. Duan M, et al. Among authors: ferris r. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6381-5. doi: 10.1016/j.bmcl.2011.08.096. Epub 2011 Aug 28. Bioorg Med Chem Lett. 2011. PMID: 21930378

4

Synthesis and evaluation of 2-phenyl-1,4-butanediamine-based CCR5 antagonists for the treatment of HIV-1.

Tallant MD, Duan M, Freeman GA, Ferris RG, Edelstein MP, Kazmierski WM, Wheelan PJ. Tallant MD, et al. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1394-8. doi: 10.1016/j.bmcl.2011.01.030. Epub 2011 Jan 11. Bioorg Med Chem Lett. 2011. PMID: 21292480

5

Discovery of N-benzyl-N'-(4-pipyridinyl)urea CCR5 antagonists as anti-HIV-1 agents (II): modification of the acyl portion.

Duan M, Peckham J, Edelstein M, Ferris R, Kazmierski WM, Spaltenstein A, Wheelan P, Xiong Z. Duan M, et al. Among authors: ferris r. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7401-4. doi: 10.1016/j.bmcl.2010.10.042. Epub 2010 Oct 21. Bioorg Med Chem Lett. 2010. PMID: 21055933

6

Novel 4,4-disubstituted piperidine-based C-C chemokine receptor-5 inhibitors with high potency against human immunodeficiency virus-1 and an improved human ether-a-go-go related gene (hERG) profile.

Kazmierski WM, Anderson DL, Aquino C, Chauder BA, Duan M, Ferris R, Kenakin T, Koble CS, Lang DG, McIntyre MS, Peckham J, Watson C, Wheelan P, Spaltenstein A, Wire MB, Svolto A, Youngman M. Kazmierski WM, et al. Among authors: ferris r. J Med Chem. 2011 Jun 9;54(11):3756-67. doi: 10.1021/jm200279v. Epub 2011 May 17. J Med Chem. 2011. PMID: 21539377

7

Discovery of bioavailable 4,4-disubstituted piperidines as potent ligands of the chemokine receptor 5 and inhibitors of the human immunodeficiency virus-1.

Kazmierski WM, Aquino C, Chauder BA, Deanda F, Ferris R, Jones-Hertzog DK, Kenakin T, Koble CS, Watson C, Wheelan P, Yang H, Youngman M. Kazmierski WM, et al. Among authors: ferris r. J Med Chem. 2008 Oct 23;51(20):6538-46. doi: 10.1021/jm800598a. Epub 2008 Sep 24. J Med Chem. 2008. PMID: 18811134

8

[2-(4-Phenyl-4-piperidinyl)ethyl]amine based CCR5 antagonists: derivatizations at the N-terminal of the piperidine ring.

Duan M, Aquino C, Ferris R, Kazmierski WM, Kenakin T, Koble C, Wheelan P, Watson C, Youngman M. Duan M, et al. Among authors: ferris r. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1610-3. doi: 10.1016/j.bmcl.2009.02.014. Epub 2009 Feb 10. Bioorg Med Chem Lett. 2009. PMID: 19233649

9

4,4-Disubstituted cyclohexylamine based CCR5 chemokine receptor antagonists as anti-HIV-1 agents.

Duan M, Aquino C, Dorsey GF Jr, Ferris R, Kazmierski WM. Duan M, et al. Among authors: ferris r. Bioorg Med Chem Lett. 2009 Sep 1;19(17):4988-92. doi: 10.1016/j.bmcl.2009.07.074. Epub 2009 Jul 18. Bioorg Med Chem Lett. 2009. PMID: 19664920

10

Rational design of potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.

Chong P, Sebahar P, Youngman M, Garrido D, Zhang H, Stewart EL, Nolte RT, Wang L, Ferris RG, Edelstein M, Weaver K, Mathis A, Peat A. Chong P, et al. J Med Chem. 2012 Dec 13;55(23):10601-9. doi: 10.1021/jm301294g. Epub 2012 Nov 26. J Med Chem. 2012. PMID: 23137340

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