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In vitro digestion testing of lipid-based delivery systems: calcium ions combine with fatty acids liberated from triglyceride rich lipid solutions to form soaps and reduce the solubilization capacity of colloidal digestion products.
Devraj R, Williams HD, Warren DB, Mullertz A, Porter CJ, Pouton CW. Devraj R, et al. Among authors: warren db. Int J Pharm. 2013 Jan 30;441(1-2):323-33. doi: 10.1016/j.ijpharm.2012.11.024. Epub 2012 Nov 23. Int J Pharm. 2013. PMID: 23178598
Choice of nonionic surfactant used to formulate type IIIA self-emulsifying drug delivery systems and the physicochemical properties of the drug have a pronounced influence on the degree of drug supersaturation that develops during in vitro digestion.
Devraj R, Williams HD, Warren DB, Porter CJ, Pouton CW. Devraj R, et al. Among authors: warren db. J Pharm Sci. 2014 Apr;103(4):1050-63. doi: 10.1002/jps.23856. Epub 2014 Jan 27. J Pharm Sci. 2014. PMID: 24470073
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