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Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization.
Igawa T, Ishii S, Tachibana T, Maeda A, Higuchi Y, Shimaoka S, Moriyama C, Watanabe T, Takubo R, Doi Y, Wakabayashi T, Hayasaka A, Kadono S, Miyazaki T, Haraya K, Sekimori Y, Kojima T, Nabuchi Y, Aso Y, Kawabe Y, Hattori K. Igawa T, et al. Among authors: higuchi y. Nat Biotechnol. 2010 Nov;28(11):1203-7. doi: 10.1038/nbt.1691. Epub 2010 Oct 17. Nat Biotechnol. 2010. PMID: 20953198
Engineered monoclonal antibody with novel antigen-sweeping activity in vivo.
Igawa T, Maeda A, Haraya K, Tachibana T, Iwayanagi Y, Mimoto F, Higuchi Y, Ishii S, Tamba S, Hironiwa N, Nagano K, Wakabayashi T, Tsunoda H, Hattori K. Igawa T, et al. Among authors: higuchi y. PLoS One. 2013 May 7;8(5):e63236. doi: 10.1371/journal.pone.0063236. Print 2013. PLoS One. 2013. PMID: 23667591 Free PMC article.
Cynomolgus monkey model of interleukin-31-induced scratching depicts blockade of human interleukin-31 receptor A by a humanized monoclonal antibody.
Oyama S, Kitamura H, Kuramochi T, Higuchi Y, Matsushita H, Suzuki T, Goto M, Adachi H, Kasutani K, Sakamoto A, Iwayanagi Y, Kaneko A, Nanami M, Fujii E, Esaki K, Takashima Y, Shimaoka S, Hattori K, Kawabe Y. Oyama S, et al. Among authors: higuchi y. Exp Dermatol. 2018 Jan;27(1):14-21. doi: 10.1111/exd.13236. Epub 2017 Apr 10. Exp Dermatol. 2018. PMID: 27714851
The effects of interleukin-6 signal blockade on immune system, reproductive and skeletal development in juvenile mice.
Sakurai T, Takai R, Bürgin H, Shioda A, Sakamoto Y, Amano J, Grimm HP, Richter WF, Higuchi Y, Chiba S, Kawamura A, Suzuki M, Müller L. Sakurai T, et al. Among authors: higuchi y. Birth Defects Res B Dev Reprod Toxicol. 2013 Apr;98(2):170-82. doi: 10.1002/bdrb.21053. Epub 2013 Mar 25. Birth Defects Res B Dev Reprod Toxicol. 2013. PMID: 23529913
Novel hyaluronic acid-methotrexate conjugates for osteoarthritis treatment.
Homma A, Sato H, Okamachi A, Emura T, Ishizawa T, Kato T, Matsuura T, Sato S, Tamura T, Higuchi Y, Watanabe T, Kitamura H, Asanuma K, Yamazaki T, Ikemi M, Kitagawa H, Morikawa T, Ikeya H, Maeda K, Takahashi K, Nohmi K, Izutani N, Kanda M, Suzuki R. Homma A, et al. Among authors: higuchi y. Bioorg Med Chem. 2009 Jul 1;17(13):4647-56. doi: 10.1016/j.bmc.2009.04.063. Epub 2009 May 3. Bioorg Med Chem. 2009. PMID: 19457673
Synthesis and optimization of hyaluronic acid-methotrexate conjugates to maximize benefit in the treatment of osteoarthritis.
Homma A, Sato H, Tamura T, Okamachi A, Emura T, Ishizawa T, Kato T, Matsuura T, Sato S, Higuchi Y, Watanabe T, Kitamura H, Asanuma K, Yamazaki T, Ikemi M, Kitagawa H, Morikawa T, Ikeya H, Maeda K, Takahashi K, Nohmi K, Izutani N, Kanda M, Suzuki R. Homma A, et al. Among authors: higuchi y. Bioorg Med Chem. 2010 Feb;18(3):1062-75. doi: 10.1016/j.bmc.2009.12.053. Epub 2009 Dec 28. Bioorg Med Chem. 2010. PMID: 20060728
1,713 results