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In vivo bone marrow microenvironment siRNA delivery using lipid-polymer nanoparticles for multiple myeloma therapy.
Guimarães PPG, Figueroa-Espada CG, Riley RS, Gong N, Xue L, Sewastianik T, Dennis PS, Loebel C, Chung A, Shepherd SJ, Haley RM, Hamilton AG, El-Mayta R, Wang K, Langer R, Anderson DG, Carrasco RD, Mitchell MJ. Guimarães PPG, et al. Among authors: riley rs. Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2215711120. doi: 10.1073/pnas.2215711120. Epub 2023 Jun 13. Proc Natl Acad Sci U S A. 2023. PMID: 37310997 Free PMC article.
Lipid Nanoparticle Composition Drives mRNA Delivery to the Placenta.
Young RE, Nelson KM, Hofbauer SI, Vijayakumar T, Alameh MG, Weissman D, Papachristou C, Gleghorn JP, Riley RS. Young RE, et al. Among authors: riley rs. bioRxiv [Preprint]. 2022 Dec 22:2022.12.22.521490. doi: 10.1101/2022.12.22.521490. bioRxiv. 2022. PMID: 36597546 Free PMC article. Preprint.
Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE).
Parhiz H, Brenner JS, Patel PN, Papp TE, Shahnawaz H, Li Q, Shi R, Zamora ME, Yadegari A, Marcos-Contreras OA, Natesan A, Pardi N, Shuvaev VV, Kiseleva R, Myerson JW, Uhler T, Riley RS, Han X, Mitchell MJ, Lam K, Heyes J, Weissman D, Muzykantov VR. Parhiz H, et al. Among authors: riley rs. J Control Release. 2022 Apr;344:50-61. doi: 10.1016/j.jconrel.2021.12.027. Epub 2021 Dec 23. J Control Release. 2022. PMID: 34953981 Free PMC article.
64 results