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226 results

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Generation and selection of novel fully human monoclonal antibodies that neutralize Dickkopf-1 (DKK1) inhibitory function in vitro and increase bone mass in vivo.
Glantschnig H, Hampton RA, Lu P, Zhao JZ, Vitelli S, Huang L, Haytko P, Cusick T, Ireland C, Jarantow SW, Ernst R, Wei N, Nantermet P, Scott KR, Fisher JE, Talamo F, Orsatti L, Reszka AA, Sandhu P, Kimmel D, Flores O, Strohl W, An Z, Wang F. Glantschnig H, et al. Among authors: sandhu p. J Biol Chem. 2010 Dec 17;285(51):40135-47. doi: 10.1074/jbc.M110.166892. Epub 2010 Oct 7. J Biol Chem. 2010. PMID: 20929859 Free PMC article.
A rate-limiting role for Dickkopf-1 in bone formation and the remediation of bone loss in mouse and primate models of postmenopausal osteoporosis by an experimental therapeutic antibody.
Glantschnig H, Scott K, Hampton R, Wei N, McCracken P, Nantermet P, Zhao JZ, Vitelli S, Huang L, Haytko P, Lu P, Fisher JE, Sandhu P, Cook J, Williams D, Strohl W, Flores O, Kimmel D, Wang F, An Z. Glantschnig H, et al. Among authors: sandhu p. J Pharmacol Exp Ther. 2011 Aug;338(2):568-78. doi: 10.1124/jpet.111.181404. Epub 2011 Apr 29. J Pharmacol Exp Ther. 2011. PMID: 21531794
Benzodiazepines as potent and selective bradykinin B1 antagonists.
Wood MR, Kim JJ, Han W, Dorsey BD, Homnick CF, DiPardo RM, Kuduk SD, MacNeil T, Murphy KL, Lis EV, Ransom RW, Stump GL, Lynch JJ, O'Malley SS, Miller PJ, Chen TB, Harrell CM, Chang RS, Sandhu P, Ellis JD, Bondiskey PJ, Pettibone DJ, Freidinger RM, Bock MG. Wood MR, et al. Among authors: sandhu p. J Med Chem. 2003 May 8;46(10):1803-6. doi: 10.1021/jm034020y. J Med Chem. 2003. PMID: 12723943
Disposition of caspofungin: role of distribution in determining pharmacokinetics in plasma.
Stone JA, Xu X, Winchell GA, Deutsch PJ, Pearson PG, Migoya EM, Mistry GC, Xi L, Miller A, Sandhu P, Singh R, deLuna F, Dilzer SC, Lasseter KC. Stone JA, et al. Among authors: sandhu p. Antimicrob Agents Chemother. 2004 Mar;48(3):815-23. doi: 10.1128/AAC.48.3.815-823.2004. Antimicrob Agents Chemother. 2004. PMID: 14982770 Free PMC article. Clinical Trial.
In-vitro metabolism of celecoxib, a cyclooxygenase-2 inhibitor, by allelic variant forms of human liver microsomal cytochrome P450 2C9: correlation with CYP2C9 genotype and in-vivo pharmacokinetics.
Tang C, Shou M, Rushmore TH, Mei Q, Sandhu P, Woolf EJ, Rose MJ, Gelmann A, Greenberg HE, De Lepeleire I, Van Hecken A, De Schepper PJ, Ebel DL, Schwartz JI, Rodrigues AD. Tang C, et al. Among authors: sandhu p. Pharmacogenetics. 2001 Apr;11(3):223-35. doi: 10.1097/00008571-200104000-00006. Pharmacogenetics. 2001. PMID: 11337938
Efficacy of caspofungin in a juvenile mouse model of central nervous system candidiasis.
Flattery AM, Hickey E, Gill CJ, Powles MA, Misura AS, Galgoci AM, Ellis JD, Zhang R, Sandhu P, Ronan J, Abruzzo GK. Flattery AM, et al. Among authors: sandhu p. Antimicrob Agents Chemother. 2011 Jul;55(7):3491-7. doi: 10.1128/AAC.01328-10. Epub 2011 Apr 25. Antimicrob Agents Chemother. 2011. PMID: 21518846 Free PMC article.
Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist.
Sarau HM, Griswold DE, Bush B, Potts W, Sandhu P, Lundberg D, Foley JJ, Schmidt DB, Webb EF, Martin LD, Legos JJ, Whitmore RG, Barone FC, Medhurst AD, Luttmann MA, Giardina GA, Hay DW. Sarau HM, et al. Among authors: sandhu p. J Pharmacol Exp Ther. 2000 Oct;295(1):373-81. J Pharmacol Exp Ther. 2000. PMID: 10992004
226 results