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Generation and selection of novel fully human monoclonal antibodies that neutralize Dickkopf-1 (DKK1) inhibitory function in vitro and increase bone mass in vivo.
Glantschnig H, Hampton RA, Lu P, Zhao JZ, Vitelli S, Huang L, Haytko P, Cusick T, Ireland C, Jarantow SW, Ernst R, Wei N, Nantermet P, Scott KR, Fisher JE, Talamo F, Orsatti L, Reszka AA, Sandhu P, Kimmel D, Flores O, Strohl W, An Z, Wang F. Glantschnig H, et al. Among authors: reszka aa. J Biol Chem. 2010 Dec 17;285(51):40135-47. doi: 10.1074/jbc.M110.166892. Epub 2010 Oct 7. J Biol Chem. 2010. PMID: 20929859 Free PMC article.
Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs.
Tan Q, Blizzard TA, Morgan JD 2nd, Birzin ET, Chan W, Yang YT, Pai LY, Hayes EC, DaSilva CA, Warrier S, Yudkovitz J, Wilkinson HA, Sharma N, Fitzgerald PM, Li S, Colwell L, Fisher JE, Adamski S, Reszka AA, Kimmel D, DiNinno F, Rohrer SP, Freedman LP, Schaeffer JM, Hammond ML. Tan Q, et al. Among authors: reszka aa. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1675-81. doi: 10.1016/j.bmcl.2005.01.046. Bioorg Med Chem Lett. 2005. PMID: 15745820
Antagonist-induced, activation function-2-independent estrogen receptor alpha phosphorylation.
Lipfert L, Fisher JE, Wei N, Scafonas A, Su Q, Yudkovitz J, Chen F, Warrier S, Birzin ET, Kim S, Chen HY, Tan Q, Schmidt A, Dininno F, Rohrer SP, Hammond ML, Rodan GA, Freedman LP, Reszka AA. Lipfert L, et al. Among authors: reszka aa. Mol Endocrinol. 2006 Mar;20(3):516-33. doi: 10.1210/me.2005-0190. Epub 2005 Oct 13. Mol Endocrinol. 2006. PMID: 16223974
Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro.
Fisher JE, Rogers MJ, Halasy JM, Luckman SP, Hughes DE, Masarachia PJ, Wesolowski G, Russell RG, Rodan GA, Reszka AA. Fisher JE, et al. Among authors: reszka aa. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):133-8. doi: 10.1073/pnas.96.1.133. Proc Natl Acad Sci U S A. 1999. PMID: 9874784 Free PMC article.
Agonist-like SERM effects on ERalpha-mediated repression of MMP1 promoter activity predict in vivo effects on bone and uterus.
Scafonas A, Reszka AA, Kimmel DB, Hou XS, Su Q, Birzin ET, Kim S, Chen HY, Tan Q, Roher SP, Dininno F, Hammond ML, Rodan GA, Towler DA, Schmidt A. Scafonas A, et al. Among authors: reszka aa. J Steroid Biochem Mol Biol. 2008 Jun;110(3-5):197-206. doi: 10.1016/j.jsbmb.2007.10.013. Epub 2008 Apr 20. J Steroid Biochem Mol Biol. 2008. PMID: 18508261
33 results