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Generation and selection of novel fully human monoclonal antibodies that neutralize Dickkopf-1 (DKK1) inhibitory function in vitro and increase bone mass in vivo.
Glantschnig H, Hampton RA, Lu P, Zhao JZ, Vitelli S, Huang L, Haytko P, Cusick T, Ireland C, Jarantow SW, Ernst R, Wei N, Nantermet P, Scott KR, Fisher JE, Talamo F, Orsatti L, Reszka AA, Sandhu P, Kimmel D, Flores O, Strohl W, An Z, Wang F. Glantschnig H, et al. Among authors: orsatti l. J Biol Chem. 2010 Dec 17;285(51):40135-47. doi: 10.1074/jbc.M110.166892. Epub 2010 Oct 7. J Biol Chem. 2010. PMID: 20929859 Free PMC article.
Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors.
Quintavalle M, Sambucini S, Summa V, Orsatti L, Talamo F, De Francesco R, Neddermann P. Quintavalle M, et al. Among authors: orsatti l. J Biol Chem. 2007 Feb 23;282(8):5536-44. doi: 10.1074/jbc.M610486200. Epub 2006 Dec 13. J Biol Chem. 2007. PMID: 17166835 Free article.
Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants.
Bottomley MJ, Cirillo A, Orsatti L, Ruggeri L, Fisher TS, Santoro JC, Cummings RT, Cubbon RM, Lo Surdo P, Calzetta A, Noto A, Baysarowich J, Mattu M, Talamo F, De Francesco R, Sparrow CP, Sitlani A, Carfí A. Bottomley MJ, et al. Among authors: orsatti l. J Biol Chem. 2009 Jan 9;284(2):1313-23. doi: 10.1074/jbc.M808363200. Epub 2008 Nov 10. J Biol Chem. 2009. PMID: 19001363 Free article.
A proprotein convertase subtilisin-like/kexin type 9 (PCSK9) C-terminal domain antibody antigen-binding fragment inhibits PCSK9 internalization and restores low density lipoprotein uptake.
Ni YG, Condra JH, Orsatti L, Shen X, Di Marco S, Pandit S, Bottomley MJ, Ruggeri L, Cummings RT, Cubbon RM, Santoro JC, Ehrhardt A, Lewis D, Fisher TS, Ha S, Njimoluh L, Wood DD, Hammond HA, Wisniewski D, Volpari C, Noto A, Lo Surdo P, Hubbard B, Carfí A, Sitlani A. Ni YG, et al. Among authors: orsatti l. J Biol Chem. 2010 Apr 23;285(17):12882-91. doi: 10.1074/jbc.M110.113035. Epub 2010 Feb 19. J Biol Chem. 2010. PMID: 20172854 Free PMC article.
Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor.
Stabile H, Mitola S, Moroni E, Belleri M, Nicoli S, Coltrini D, Peri F, Pessi A, Orsatti L, Talamo F, Castronovo V, Waltregny D, Cotelli F, Ribatti D, Presta M. Stabile H, et al. Among authors: orsatti l. Blood. 2007 Mar 1;109(5):1834-40. doi: 10.1182/blood-2006-06-032276. Epub 2006 Oct 31. Blood. 2007. PMID: 17077323 Free article.
Differential screening of phage-ab libraries by oligonucleotide microarray technology.
Monaci P, Luzzago A, Santini C, De Pra A, Arcuri M, Magistri F, Bellini A, Ansuini H, Ambrosio M, Ammendola V, Bigotti MG, Cirillo A, Nuzzo M, Nasti AA, Neuner P, Orsatti L, Pezzanera M, Sbardellati A, Silvestre G, Uva P, Viti V, Barbato G, Colloca S, Demartis A, De Rinaldis E, Giampaoli S, Lahm A, Palombo F, Talamo F, Vitelli A, Nicosia A, Cortese R. Monaci P, et al. Among authors: orsatti l. PLoS One. 2008 Jan 30;3(1):e1508. doi: 10.1371/journal.pone.0001508. PLoS One. 2008. PMID: 18231595 Free PMC article.
PP2A regulates HDAC4 nuclear import.
Paroni G, Cernotta N, Dello Russo C, Gallinari P, Pallaoro M, Foti C, Talamo F, Orsatti L, Steinkühler C, Brancolini C. Paroni G, et al. Among authors: orsatti l. Mol Biol Cell. 2008 Feb;19(2):655-67. doi: 10.1091/mbc.e07-06-0623. Epub 2007 Nov 28. Mol Biol Cell. 2008. PMID: 18045992 Free PMC article.
39 results