Ihara Y - Search Results

1

The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.

Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M. Mori K, et al. Among authors: ihara y. Psychogeriatrics. 2010 Sep;10(3):117-23. doi: 10.1111/j.1479-8301.2010.00330.x. Psychogeriatrics. 2010. PMID: 20860566 Free article.

2

γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43.

Okochi M, Tagami S, Yanagida K, Takami M, Kodama TS, Mori K, Nakayama T, Ihara Y, Takeda M. Okochi M, et al. Among authors: ihara y. Cell Rep. 2013 Jan 31;3(1):42-51. doi: 10.1016/j.celrep.2012.11.028. Epub 2013 Jan 3. Cell Rep. 2013. PMID: 23291095 Free article.

3

gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.

Takami M, Nagashima Y, Sano Y, Ishihara S, Morishima-Kawashima M, Funamoto S, Ihara Y. Takami M, et al. Among authors: ihara y. J Neurosci. 2009 Oct 14;29(41):13042-52. doi: 10.1523/JNEUROSCI.2362-09.2009. J Neurosci. 2009. PMID: 19828817 Free PMC article.

4

γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment.

Matsumura N, Takami M, Okochi M, Wada-Kakuda S, Fujiwara H, Tagami S, Funamoto S, Ihara Y, Morishima-Kawashima M. Matsumura N, et al. Among authors: ihara y. J Biol Chem. 2014 Feb 21;289(8):5109-21. doi: 10.1074/jbc.M113.510131. Epub 2013 Dec 28. J Biol Chem. 2014. PMID: 24375443 Free PMC article.

5

Alanine substitutions in the GXXXG motif alter C99 cleavage by γ-secretase but not its dimerization.

Higashide H, Ishihara S, Nobuhara M, Ihara Y, Funamoto S. Higashide H, et al. Among authors: ihara y. J Neurochem. 2017 Mar;140(6):955-962. doi: 10.1111/jnc.13942. Epub 2017 Jan 30. J Neurochem. 2017. PMID: 28032911 Free article.

6

Semagacestat Is a Pseudo-Inhibitor of γ-Secretase.

Tagami S, Yanagida K, Kodama TS, Takami M, Mizuta N, Oyama H, Nishitomi K, Chiu YW, Okamoto T, Ikeuchi T, Sakaguchi G, Kudo T, Matsuura Y, Fukumori A, Takeda M, Ihara Y, Okochi M. Tagami S, et al. Among authors: ihara y. Cell Rep. 2017 Oct 3;21(1):259-273. doi: 10.1016/j.celrep.2017.09.032. Cell Rep. 2017. PMID: 28978478 Free article.

7

Switched Aβ43 generation in familial Alzheimer's disease with presenilin 1 mutation.

Kakuda N, Takami M, Okochi M, Kasuga K, Ihara Y, Ikeuchi T. Kakuda N, et al. Among authors: ihara y. Transl Psychiatry. 2021 Nov 3;11(1):558. doi: 10.1038/s41398-021-01684-1. Transl Psychiatry. 2021. PMID: 34728605 Free PMC article.

8

Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.

Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A. Shimojo M, et al. Among authors: ihara y. J Biol Chem. 2008 Jun 13;283(24):16488-96. doi: 10.1074/jbc.M801279200. Epub 2008 Apr 21. J Biol Chem. 2008. PMID: 18430735 Free article.

9

The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells.

Kokawa A, Ishihara S, Fujiwara H, Nobuhara M, Iwata M, Ihara Y, Funamoto S. Kokawa A, et al. Among authors: ihara y. Acta Neuropathol Commun. 2015 Nov 4;3:66. doi: 10.1186/s40478-015-0247-6. Acta Neuropathol Commun. 2015. PMID: 26531305 Free PMC article.

10

Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase.

Kakuda N, Funamoto S, Yagishita S, Takami M, Osawa S, Dohmae N, Ihara Y. Kakuda N, et al. Among authors: ihara y. J Biol Chem. 2006 May 26;281(21):14776-86. doi: 10.1074/jbc.M513453200. Epub 2006 Apr 4. J Biol Chem. 2006. PMID: 16595682 Free article.

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