Sinclair PR - Search Results

1

Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal.

Correia MA, Sinclair PR, De Matteis F. Correia MA, et al. Among authors: sinclair pr. Drug Metab Rev. 2011 Feb;43(1):1-26. doi: 10.3109/03602532.2010.515222. Epub 2010 Sep 23. Drug Metab Rev. 2011. PMID: 20860521 Free PMC article. Review.

2

Role of cytochrome P450 1A2 in bilirubin degradation Studies in Cyp1a2 (-/-) mutant mice.

Zaccaro C, Sweitzer S, Pipino S, Gorman N, Sinclair PR, Sinclair JF, Nebert DW, De Matteis F. Zaccaro C, et al. Among authors: sinclair pr, sinclair jf. Biochem Pharmacol. 2001 Apr 1;61(7):843-9. doi: 10.1016/s0006-2952(01)00568-8. Biochem Pharmacol. 2001. PMID: 11274970

3

Formation of cobalt protoporphyrin in the liver of rats. A mechanism for the inhibition of liver haem biosynthesis by inorganic cobalt.

Sinclair P, Gibbs AH, Sinclair JF, de Matteis F. Sinclair P, et al. Biochem J. 1979 Mar 15;178(3):529-38. doi: 10.1042/bj1780529. Biochem J. 1979. PMID: 454362 Free PMC article.

4

Formation of cobalt protoporphyrin by chicken hepatocytes in culture. Relationship to decrease of 5-aminolaevulinate synthase caused by cobalt.

Sinclair PR, Sinclair JF, Bonkowsky HL, Gibbs AH, De Matteis F. Sinclair PR, et al. Among authors: sinclair jf. Biochem Pharmacol. 1982 Mar 15;31(6):993-9. doi: 10.1016/0006-2952(82)90333-1. Biochem Pharmacol. 1982. PMID: 7082380

5

Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes.

Noreault TL, Kostrubsky VE, Wood SG, Nichols RC, Strom SC, Trask HW, Wrighton SA, Evans RM, Jacobs JM, Sinclair PR, Sinclair JF. Noreault TL, et al. Among authors: sinclair pr, sinclair jf. Drug Metab Dispos. 2005 Jul;33(7):993-1003. doi: 10.1124/dmd.105.003954. Epub 2005 Apr 15. Drug Metab Dispos. 2005. PMID: 15833926

6

Uroporphyrinogen oxidation catalyzed by human cytochromes P450.

Sinclair PR, Gorman N, Tsyrlov IB, Fuhr U, Walton HS, Sinclair JF. Sinclair PR, et al. Among authors: sinclair jf. Drug Metab Dispos. 1998 Oct;26(10):1019-25. Drug Metab Dispos. 1998. PMID: 9763408

7

Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice.

Sinclair PR, Gorman N, Dalton T, Walton HS, Bement WJ, Sinclair JF, Smith AG, Nebert DW. Sinclair PR, et al. Among authors: sinclair jf. Biochem J. 1998 Feb 15;330 ( Pt 1)(Pt 1):149-53. doi: 10.1042/bj3300149. Biochem J. 1998. PMID: 9461503 Free PMC article.

8

Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron.

Gorman N, Ross KL, Walton HS, Bement WJ, Szakacs JG, Gerhard GS, Dalton TP, Nebert DW, Eisenstein RS, Sinclair JF, Sinclair PR. Gorman N, et al. Among authors: sinclair pr, sinclair jf. Hepatology. 2002 Apr;35(4):912-21. doi: 10.1053/jhep.2002.32487. Hepatology. 2002. PMID: 11915039

9

CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene and iron.

Sinclair PR, Gorman N, Walton HS, Bement WJ, Dalton TP, Sinclair JF, Smith AG, Nebert DW. Sinclair PR, et al. Among authors: sinclair jf. Toxicol Appl Pharmacol. 2000 Jan 1;162(1):60-7. doi: 10.1006/taap.1999.8832. Toxicol Appl Pharmacol. 2000. PMID: 10631128 Free article.

10

Protection of the Cyp1a2(-/-) null mouse against uroporphyria and hepatic injury following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Smith AG, Clothier B, Carthew P, Childs NL, Sinclair PR, Nebert DW, Dalton TP. Smith AG, et al. Among authors: sinclair pr. Toxicol Appl Pharmacol. 2001 Jun 1;173(2):89-98. doi: 10.1006/taap.2001.9167. Toxicol Appl Pharmacol. 2001. PMID: 11384210

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