Olaharski AJ - Search Results

1

GADD45α induction in the GreenScreen HC indicator assay does not occur independently of cytotoxicity.

Olaharski AJ, Albertini S, Mueller L, Zeller A, Struwe M, Gocke E, Kolaja K. Olaharski AJ, et al. Environ Mol Mutagen. 2011 Jan;52(1):28-34. doi: 10.1002/em.20565. Environ Mol Mutagen. 2011. PMID: 20839224

2

Evaluation of the GreenScreen GADD45alpha-GFP indicator assay with non-proprietary and proprietary compounds.

Olaharski A, Albertini S, Kirchner S, Platz S, Uppal H, Lin H, Kolaja K. Olaharski A, et al. Mutat Res. 2009 Jan;672(1):10-6. doi: 10.1016/j.mrgentox.2008.08.019. Epub 2008 Sep 4. Mutat Res. 2009. PMID: 18812235

3

In vitro to in vivo concordance of a high throughput assay of bone marrow toxicity across a diverse set of drug candidates.

Olaharski AJ, Uppal H, Cooper M, Platz S, Zabka TS, Kolaja KL. Olaharski AJ, et al. Toxicol Lett. 2009 Jul 24;188(2):98-103. doi: 10.1016/j.toxlet.2009.03.012. Epub 2009 Mar 25. Toxicol Lett. 2009. PMID: 19446241

4

Identification of a kinase profile that predicts chromosome damage induced by small molecule kinase inhibitors.

Olaharski AJ, Gonzaludo N, Bitter H, Goldstein D, Kirchner S, Uppal H, Kolaja K. Olaharski AJ, et al. PLoS Comput Biol. 2009 Jul;5(7):e1000446. doi: 10.1371/journal.pcbi.1000446. Epub 2009 Jul 24. PLoS Comput Biol. 2009. PMID: 19629159 Free PMC article.

5

Modeling bone marrow toxicity using kinase structural motifs and the inhibition profiles of small molecular kinase inhibitors.

Olaharski AJ, Bitter H, Gonzaludo N, Kondru R, Goldstein DM, Zabka TS, Lin H, Singer T, Kolaja K. Olaharski AJ, et al. Toxicol Sci. 2010 Nov;118(1):266-75. doi: 10.1093/toxsci/kfq258. Epub 2010 Sep 1. Toxicol Sci. 2010. PMID: 20810542

6

Development and evaluation of a genomic signature for the prediction and mechanistic assessment of nongenotoxic hepatocarcinogens in the rat.

Fielden MR, Adai A, Dunn RT 2nd, Olaharski A, Searfoss G, Sina J, Aubrecht J, Boitier E, Nioi P, Auerbach S, Jacobson-Kram D, Raghavan N, Yang Y, Kincaid A, Sherlock J, Chen SJ, Car B; Predictive Safety Testing Consortium, Carcinogenicity Working Group. Fielden MR, et al. Toxicol Sci. 2011 Nov;124(1):54-74. doi: 10.1093/toxsci/kfr202. Epub 2011 Aug 2. Toxicol Sci. 2011. PMID: 21813463

7

Interlaboratory evaluation of genomic signatures for predicting carcinogenicity in the rat.

Fielden MR, Nie A, McMillian M, Elangbam CS, Trela BA, Yang Y, Dunn RT 2nd, Dragan Y, Fransson-Stehen R, Bogdanffy M, Adams SP, Foster WR, Chen SJ, Rossi P, Kasper P, Jacobson-Kram D, Tatsuoka KS, Wier PJ, Gollub J, Halbert DN, Roter A, Young JK, Sina JF, Marlowe J, Martus HJ, Aubrecht J, Olaharski AJ, Roome N, Nioi P, Pardo I, Snyder R, Perry R, Lord P, Mattes W, Car BD; Predictive Safety Testing Consortium; Carcinogenicity Working Group. Fielden MR, et al. Among authors: olaharski aj. Toxicol Sci. 2008 May;103(1):28-34. doi: 10.1093/toxsci/kfn022. Epub 2008 Feb 14. Toxicol Sci. 2008. PMID: 18281259

8

Chromosomal malsegregation and micronucleus induction in vitro by the DNA topoisomerase II inhibitor fisetin.

Olaharski AJ, Mondrala ST, Eastmond DA. Olaharski AJ, et al. Mutat Res. 2005 Apr 4;582(1-2):79-86. doi: 10.1016/j.mrgentox.2005.01.002. Mutat Res. 2005. PMID: 15781213

9

Biomarkers of carcinogenicity and their roles in drug discovery and development.

Guan P, Olaharski A, Fielden M, Roome N, Dragan Y, Sina J. Guan P, et al. Expert Rev Clin Pharmacol. 2008 Nov;1(6):759-71. doi: 10.1586/17512433.1.6.759. Expert Rev Clin Pharmacol. 2008. PMID: 24410606

10

Pharmacological inhibition of polo like kinase 2 (PLK2) does not cause chromosomal damage or result in the formation of micronuclei.

Fitzgerald K, Bergeron M, Willits C, Bowers S, Aubele DL, Goldbach E, Tonn G, Ness D, Olaharski A. Fitzgerald K, et al. Toxicol Appl Pharmacol. 2013 May 15;269(1):1-7. doi: 10.1016/j.taap.2013.02.012. Epub 2013 Mar 1. Toxicol Appl Pharmacol. 2013. PMID: 23466428

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