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Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion.
Heni M, Ketterer C, Thamer C, Herzberg-Schäfer SA, Guthoff M, Stefan N, Machicao F, Staiger H, Fritsche A, Häring HU. Heni M, et al. Among authors: herzberg schafer sa. Diabetes. 2010 Dec;59(12):3247-52. doi: 10.2337/db10-0674. Epub 2010 Aug 29. Diabetes. 2010. PMID: 20802253 Free PMC article.
Nor-1, a novel incretin-responsive regulator of insulin genes and insulin secretion.
Ordelheide AM, Gerst F, Rothfuss O, Heni M, Haas C, Thielker I, Herzberg-Schäfer S, Böhm A, Machicao F, Ullrich S, Stefan N, Fritsche A, Häring HU, Staiger H. Ordelheide AM, et al. Mol Metab. 2013 Jun 17;2(3):243-55. doi: 10.1016/j.molmet.2013.06.003. eCollection 2013. Mol Metab. 2013. PMID: 24044104 Free PMC article.
Polymorphism rs11085226 in the gene encoding polypyrimidine tract-binding protein 1 negatively affects glucose-stimulated insulin secretion.
Heni M, Ketterer C, Wagner R, Linder K, Böhm A, Herzberg-Schäfer SA, Machicao F, Knoch KP, Fritsche A, Staiger H, Häring HU, Solimena M. Heni M, et al. Among authors: herzberg schafer sa. PLoS One. 2012;7(10):e46154. doi: 10.1371/journal.pone.0046154. Epub 2012 Oct 15. PLoS One. 2012. PMID: 23077502 Free PMC article.
The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway.
't Hart LM, Fritsche A, Nijpels G, van Leeuwen N, Donnelly LA, Dekker JM, Alssema M, Fadista J, Carlotti F, Gjesing AP, Palmer CN, van Haeften TW, Herzberg-Schäfer SA, Simonis-Bik AM, Houwing-Duistermaat JJ, Helmer Q, Deelen J, Guigas B, Hansen T, Machicao F, Willemsen G, Heine RJ, Kramer MH, Holst JJ, de Koning EJ, Häring HU, Pedersen O, Groop L, de Geus EJ, Slagboom PE, Boomsma DI, Eekhoff EM, Pearson ER, Diamant M. 't Hart LM, et al. Among authors: herzberg schafer sa. Diabetes. 2013 Sep;62(9):3275-81. doi: 10.2337/db13-0227. Epub 2013 May 14. Diabetes. 2013. PMID: 23674605 Free PMC article. Clinical Trial.