Wals HC - Search Results

1

Two distinct classes of novel pyrazolinecarboxamides as potent cannabinoid CB1 receptor agonists.

Lange JH, Attali A, van der Neut MA, Wals HC, Mulder A, Zilaout H, Duursma A, van Aken HH, van Vliet BJ. Lange JH, et al. Among authors: wals hc. Bioorg Med Chem Lett. 2010 Sep 1;20(17):4992-8. doi: 10.1016/j.bmcl.2010.07.056. Epub 2010 Jul 17. Bioorg Med Chem Lett. 2010. PMID: 20688519

2

Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists.

Lange JH, Coolen HK, van Stuivenberg HH, Dijksman JA, Herremans AH, Ronken E, Keizer HG, Tipker K, McCreary AC, Veerman W, Wals HC, Stork B, Verveer PC, den Hartog AP, de Jong NM, Adolfs TJ, Hoogendoorn J, Kruse CG. Lange JH, et al. Among authors: wals hc. J Med Chem. 2004 Jan 29;47(3):627-43. doi: 10.1021/jm031019q. J Med Chem. 2004. PMID: 14736243

3

Bioisosteric replacements of the pyrazole moiety of rimonabant: synthesis, biological properties, and molecular modeling investigations of thiazoles, triazoles, and imidazoles as potent and selective CB1 cannabinoid receptor antagonists.

Lange JH, van Stuivenberg HH, Coolen HK, Adolfs TJ, McCreary AC, Keizer HG, Wals HC, Veerman W, Borst AJ, de Looff W, Verveer PC, Kruse CG. Lange JH, et al. Among authors: wals hc. J Med Chem. 2005 Mar 24;48(6):1823-38. doi: 10.1021/jm040843r. J Med Chem. 2005. PMID: 15771428

4

Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity.

Lange JH, van Stuivenberg HH, Veerman W, Wals HC, Stork B, Coolen HK, McCreary AC, Adolfs TJ, Kruse CG. Lange JH, et al. Among authors: wals hc. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4794-8. doi: 10.1016/j.bmcl.2005.07.054. Bioorg Med Chem Lett. 2005. PMID: 16140010

5

Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB2 receptor antagonists with high binding efficiencies.

Lange JH, van der Neut MA, Wals HC, Kuil GD, Borst AJ, Mulder A, den Hartog AP, Zilaout H, Goutier W, van Stuivenberg HH, van Vliet BJ. Lange JH, et al. Among authors: wals hc. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1084-9. doi: 10.1016/j.bmcl.2009.12.032. Epub 2009 Dec 11. Bioorg Med Chem Lett. 2010. PMID: 20031412

6

Synthesis, SAR and intramolecular hydrogen bonding pattern of 1,3,5-trisubstituted 4,5-dihydropyrazoles as potent cannabinoid CB(1) receptor antagonists.

Lange JH, van der Neut MA, den Hartog AP, Wals HC, Hoogendoorn J, van Stuivenberg HH, van Vliet BJ, Kruse CG. Lange JH, et al. Among authors: wals hc. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1752-7. doi: 10.1016/j.bmcl.2010.01.049. Epub 2010 Jan 20. Bioorg Med Chem Lett. 2010. PMID: 20137935

7

Design, synthesis and biological activity of rigid cannabinoid CB1 receptor antagonists.

Stoit AR, Lange JH, Hartog AP, Ronken E, Tipker K, Stuivenberg HH, Dijksman JA, Wals HC, Kruse CG. Stoit AR, et al. Among authors: wals hc. Chem Pharm Bull (Tokyo). 2002 Aug;50(8):1109-13. doi: 10.1248/cpb.50.1109. Chem Pharm Bull (Tokyo). 2002. PMID: 12192147 Free article.

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